Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice

Henning, Susanne M.; Yang, Jieping; Hsu, Mark; Lee, Ru-Po; Grojean, Emma M; Ly, Austin; Tseng, Chi‐Hong; Heber, David; Li, Zhaoping

doi:10.1007/s00394-017-1542-8

Cited by 179 publications

(130 citation statements)

References 37 publications

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“…Consistent with our data, other studies have shown that many plant extracts rich in catechins and methylxanthines, like guarana, may activate AMPK concomitantly with reducing weight (Henning et al, ) and increase energy expenditure (Yoneshiro et al, ). Interestingly, when administered together, catechin and caffeine increase energy expenditure in subjects with metabolically active BAT but not in subjects with negligible activity (Yoneshiro et al, ), suggesting that the anti‐obesity effect of catechin and caffeine occurs via BAT activation.…”

Section: Discussionsupporting

confidence: 93%

Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation

Bortolin

Vargas

Ramos

et al. 2019

Phytotherapy Research

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Obesity is a metabolic disorder associated with adverse health consequences that has increased worldwide at an epidemic rate. This has encouraged many people to utilize nonprescription herbal supplements for weight loss without knowledge of their safety or efficacy. However, mounting evidence has shown that some herbal supplements used for weight loss are associated with adverse effects. Guarana seed powder is a popular nonprescription dietary herb supplement marketed for weight loss, but no study has demonstrated its efficacy or safety when administered alone. Wistar rats were fed four different diets (low‐fat diet and Western diet with or without guarana supplementation) for 18 weeks. Metabolic parameters, gut microbiota changes, and toxicity were then characterized. Guarana seed powder supplementation prevented weight gain, insulin resistance, and adipokine dysregulation induced by Western diet compared with the control diet. Guarana induced brown adipose tissue expansion, mitochondrial biogenesis, uncoupling protein‐1 overexpression, AMPK activation, and minor changes in gut microbiota. Molecular docking suggested a direct activation of AMPK by four guarana compounds tested here. We propose that brown adipose tissue activation is one of the action mechanisms involved in guarana supplementation‐induced weight loss and that direct AMPK activation may underlie this mechanism. In summary, guarana is an attractive potential therapeutic agent to treat obesity.

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Section: Discussionsupporting

confidence: 93%

Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation

Bortolin

Vargas

Ramos

et al. 2019

Phytotherapy Research

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show abstract

“…However, there has been a lack of conclusive data on the specific phylum(s) of microbiota that was responsible for the anti‐obesity effect observed in these previous studies. For instance, some studies reported that F/B ratio was downregulated by polyphenols or Chinese herbal extracts with anti‐obesity bioactivity, while the protective effect of berberine against HFD‐induced obesity was not associated with any significant change of F/B ratio . In the current study, NLE treatment helped to maintain the F/B ratio at a level similar to that of the NCD group, which might contribute to its anti‐obesity effect.…”

Section: Discussionmentioning

confidence: 43%

“…Emerging evidence supports the benefits of a favorable profile of GM in weight management . Many natural products, including plant foods and phytochemicals, have been found to be effective in weight management by modulating GM . However, there has been a lack of conclusive data on the specific phylum(s) of microbiota that was responsible for the anti‐obesity effect observed in these previous studies.…”

Section: Discussionmentioning

confidence: 99%

Extract of the Microalga Nitzschia laevis Prevents High‐Fat‐Diet‐Induced Obesity in Mice by Modulating the Composition of Gut Microbiota

Guo

Liu

Wei

et al. 2018

Molecular Nutrition Food Res

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Scope The aim of the present study is to investigate the efficacy of Nitzschia laevis extract (NLE) in preventing obesity in mice fed with a high‐fat diet (HFD), and the potential underlying mechanisms focusing on modulation of the gut microbiota profile. Methods and results Physiological, histological, and biochemical parameters and gut microbiota compositions are compared among four experimental groups fed respectively with the following diets for 8 weeks: Normal chow diet, HFD, HFD + low concentration of NLE, and HFD + high concentration of NLE. The results demonstrate that NLE supplementation significantly reduces body weight gain and effectively prevents lipid accumulation in the white adipose tissue and liver of the mice. Mechanistic analysis reveals that NLE promotes the expression of uncoupling protein 1 and peroxisome proliferators‐activated receptor‐γ coactivator‐1 mRNA in brown adipose tissue. Furthermore, NLE protects the gut epithelium and positively reshapes the gut microbiota composition against the damaging effect of HFD. Conclusions NLE supplementation demonstrates a protective effect against HFD‐induced obesity in mice, which is associated with reshaping the profile of gut microbiota. To the best of our knowledge, this has been the first report on the potential of microalgal extract to prevent obesity by modulating gut microbiota.

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“…Eubacterium is involved in cholesterol and bile acid metabolism pathways and can produce butyrate . One of the potential mechanisms between microbiota and weight control might be the fermentation of polysaccharides to SCFAs . In our previous study conducted in vitro , a higher concentration of SCFAs, compared to the control, was observed in the cultures with oolong tea polyphenols .…”

Section: Resultsmentioning

confidence: 92%

A metagenomic analysis of the modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiome in a high‐fat diet‐induced obesity mouse model

et al. 2019

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BACKGROUND As a result of a low bioavailability, the majority of Cyclocarya paliurus flavonoids (CPF) remain in the large intestine where they accumulate to exert a modulatory effect on the intestinal micro‐ecology. Therefore, the present study investigated the modulatory effect of CPF on intestinal microbiota. RESULTS CPF dramatically ameliorated the obesity‐induced gut dysbiosis. A significant decrease (P < 0.05) was observed in the ratio of Firmicutes/Bacteroidetes after CPF treatment for 8 weeks. Moreover, Kyoto Encyclopedia of Genes and Genomes pathways of biosynthesis of amino acids, the two‐component system and ATP‐binding cassette transporters enriched the most differentially expressed genes after CPF intervention. CONCLUSION The results of the present study indicate that CPF might have prebiotic‐like activity and could be used as a functional food component with potential therapeutic utility to prevent obesity‐related metabolic disorders by manipulating the gut flora and affecting certain metabolic pathways, thus contributing to the improvement of human health. © 2019 Society of Chemical Industry

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Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice

Cited by 179 publications

References 37 publications

Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation

Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation

Extract of the Microalga Nitzschia laevis Prevents High‐Fat‐Diet‐Induced Obesity in Mice by Modulating the Composition of Gut Microbiota

A metagenomic analysis of the modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiome in a high‐fat diet‐induced obesity mouse model

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