Debut of Leber's hereditary optic neuropathy. Macular segmentation analysis using optical coherence tomography

Santos-Bueso, E.; Asorey-García, A.; Porta‐Etessam, J.; Vinuesa-Silva, J.M.; García–Sánchez, J.

doi:10.1016/j.oftale.2015.05.005

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2018

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“…As it has been previously reported, the temporal fibres of the peripapillary retinal nerve fibre layer were the most severely affected in our patient, with relative sparing of the nasal ones . Recent publications have reported changes in the macular ganglion cell layer in patients with LHON during the initial days of visual loss, and have suggested these changes may precede the conversion from carrier to disease status …”

Section: Discussionsupporting

confidence: 81%

“…Optical coherence tomography (OCT) has improved our understanding of LHON . It has been reported that the evaluation of the macular ganglion cell layer would be better correlated to visual loss in LHON than the peripapillary retinal nerve fibre layer . Ganglion cell loss is detected earlier in the macular region due to the presence of edema at the optic nerve in the acute phase .…”

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confidence: 99%

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