Debulking surgery for advanced thymoma

Liu, H.-C.; Chen, Y.-J.; Tzen, Chin Yuan; Huang, Che-Jen; Chang, Cheng-Chieh; Huang, Wen‐Chen

doi:10.1016/j.ejso.2006.03.049

Cited by 30 publications

(28 citation statements)

References 32 publications

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“…On the other hand, the role of ‘debulking' surgery, in patients in whom complete resection is not feasible, remains unclear. Although some have suggested it to be beneficial (Liu et al , 2006), others reported that it could not affect the outcome as compared with biopsy only, followed by radiotherapy (Ciernik et al , 1994). …”

Section: Discussionmentioning

confidence: 99%

A phase II trial of dose-dense chemotherapy, followed by surgical resection and/or thoracic radiotherapy, in locally advanced thymoma: report of a Japan Clinical Oncology Group trial (JCOG 9606)

Kunitoh

Tamura

Shibata³

et al. 2010

Br J Cancer

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Background:This study aimed to evaluate the safety and efficacy of dose-dense weekly chemotherapy, followed by resection and/or thoracic radiotherapy.Methods:Patients with histologically documented thymoma with unresectable stage III disease received 9 weeks of chemotherapy: cisplatin 25 mg m−2 on weeks 1–9; vincristine 1 mg m−2 on weeks 1, 2, 4, 6 and 8; and doxorubicin 40 mg m−2 and etoposide 80 mg m−2 on days 1–3 of weeks 1, 3, 5, 7 and 9. Patients went on to surgery and post-operative radiotherapy of 48 Gy; those with unresectable disease received 60 Gy radiotherapy.Results:total of 23 patients were entered. The main toxicities of the chemotherapy regimen were neutropenia and anaemia, and 57% of patients completed the planned 9 weeks of therapy. There were no toxic deaths. Of the 21 eligible patients, 13 (62%) achieved a partial response (95% confidence interval: 38–82%). Thirteen patients underwent a thoracotomy and nine (39%) underwent complete resection. Progression-free survival at 2 and 5 years was 80 and 43%, respectively. Overall survival at 5 and 8 years was 85 and 69%, respectively. Survival did not seem to be affected by resection.Conclusion:In thymoma patients, weekly dose-dense chemotherapy has activity similar to that of conventional regimens. Although some patients could achieve complete resection, the role of surgery remains unclear.

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Section: Discussionmentioning

confidence: 99%

A phase II trial of dose-dense chemotherapy, followed by surgical resection and/or thoracic radiotherapy, in locally advanced thymoma: report of a Japan Clinical Oncology Group trial (JCOG 9606)

Kunitoh

Tamura

Shibata³

et al. 2010

Br J Cancer

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“…[17][18][19] However, a subtotal resection may decrease the size of the radiation field and radiation dose needed, reducing damage to surrounding organs. 20,21 In some patients it may be prudent to avoid extensive surgery unless there is a reasonable chance of complete resection.…”

Section: Figure 3 A-dmentioning

confidence: 99%

Preoperative Computed Tomography Findings Predict Surgical Resectability of Thymoma

Hayes

Huang

Plodkowski

et al. 2014

Journal of Thoracic Oncology

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“…Role of debulking or subtotal resection is controversial with conflicting datas in favour and against [26,27]. Partial resection has been argued to provide better survival than a simple biopsy in unresectable cases [28].…”

Section: Role Of Surgerymentioning

confidence: 99%

A Review of Thymic Tumors

Bushan

Sharma

Verma

2013

Indian J Surg Oncol

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Thymic tumors represent 0.2-1.5 % of all malignancies with an incidence of 0.15 per 100,000 population. Thymic tumors are most common tumors of the anterior mediastinum accounting for 20 % of all mediastinal tumors and 50 % of all anterior mediastinal tumors. Over 90 % of all thymic tumors occur in anterior mediastinum, remainder occurring in neck or other mediastinal areas especially aortopulmonary window and retro cardiac area which are common sites for ectopic thymic tissues and possible explanation for failure in some cases of simple thymectomy to improve Myasthenia Gravis(MG). The aim of this review is to discuss histologic classification, diagnostic features, evaluation, management and prognosis of thymic tumors.

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Debulking surgery for advanced thymoma

Cited by 30 publications

References 32 publications

A phase II trial of dose-dense chemotherapy, followed by surgical resection and/or thoracic radiotherapy, in locally advanced thymoma: report of a Japan Clinical Oncology Group trial (JCOG 9606)

A phase II trial of dose-dense chemotherapy, followed by surgical resection and/or thoracic radiotherapy, in locally advanced thymoma: report of a Japan Clinical Oncology Group trial (JCOG 9606)

Preoperative Computed Tomography Findings Predict Surgical Resectability of Thymoma

A Review of Thymic Tumors

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