Deboronation of C-substituted ortho- and meta-closo-carboranes using “wet” fluoride ion solutions

Nucleoside-metallacarborane conjugates - synthesis of a uridine - bearing 3,3,3-(CO)3-closo-3,1,2-ReC2B9H10 complex

“…[25][26][27] Reports on the direct formation of metallacarboranes from closo-carboranes were published by Hawthorne. 28 Re-carborane complexes can be prepared in aqueous solution using different sources of fluoride ions to degrade closo-carboranes to yield nido-carboranes to facilitate the formation of the desired Recarborane complexes directly from the closo forms.…”

Carboranylporphyrazines for anti-cancer therapies: synthesis and physicochemical properties

“…During this step, the o-carborane cages, owing to their sensitivity to even moderately strong nucleophiles -including the templating agent Mg II (n-OPr) 2 in n-PrOH -may undergo significant chemical and structural changes, affording complex mixtures of anionic (nido) species. It is well known, indeed, that treatment of o-carboranes with different nucleophiles, including alkaline-metal alkoxides, represents a useful synthetic tool for inducing the closo→nido conversion of the carborane cage [57][58][59][60][61][62].…”

Extraction with Metal Bis(dicarbollide) Anions

“…The icosahedral o-carborane cage undergoes one boron degradation in position B(3) (or symmetrically equivalent B(6) in the parent unsubstituted compound) when treated with a large variety of basic reagents with the formation of the [7,8-C2B9H11] -(dicarbollide) anion [56,57]. Typically, NaOH or KOH in methanol or ethanol are used [58] for the unsubstituted compound, although numerous other reagents and conditions were designed using organic bases or the Fion [59][60][61][62][63][64][65][66][67][68][69]. These are, in turn, particularly useful in the synthesis of substituted and less stable ions.…”