“…Patients with coronary heart failure, cerebrovascular disease or peripheral vascular disease were excluded from the study. Both hypertensives and control subjects were classified according to age into those younger than and those older than 40 In addition to the classic pulsed Doppler method,9 12 the present apparatus (Echovar Doppler pulse, Alvar Electronic) has two main original characteristics: the pulsed emission is associated with an adjustable rangegated time system and a double transducer system provides a bidimensional blood velocity measurement, which considerably minimizes the errors induced by the observation angle between the ultrasonic beam and the vessel axis.…”
SUMMARY Diameter, blood flow velocity and volumic flow of the brachial artery were measured in 36 patients with sustained essential hypertension and compared with 25 normal subjects. Both hypertensives and control subjects were classified according to age into those younger than and those older than 40 years. For the determinations, a pulsed Doppler velocimeter with an adjustable range-gated time system and a double transducer probe was used. With the apparatus, the error in the determination of the angle between the ultrasound beam and the flowing stream of blood was less than 2%. In addition, the overestimation of the arterial diameter due to the sample volume size did not exceed 0.035 ± 0.015 cm. In hypertensives, the diameter of the brachial artery was significantly increased. The value was 0.482 ± 0.013 cm in subjects younger than 40 years and 0.517 ± 0,013 cm in those older than 40 years; in the corresponding controls, the values were 0.422 ± 0.011 cm and 0.436 + 0.013 cm (p < 0.01; p < 0.001). Blood flow velocity was reduced (p < 0.05; p < 0.01) and volumic flow remained within normal ranges. Both in the younger and the older groups, a significant positive correlation was observed between mean arterial pressure and the arterial diameter (r = 0.75; r = 0.60). In hypertensives, i.v. dihydralazine decreased mean arterial pressure from 120 ± 7 to 102 ± 7 mm Hg (p < 0.001). Arterial diameter also significantly decreased (p < 0.01) and returned toward normal. The study demonstrated that the diameter of the brachial artery was significantly increased in sustained essential hypertension and suggested that, with the chronic elevation of blood pressure, the large arteries dilate excessively, contributing to the maintainence of arterial blood flow within normal ranges.LARGE ARTERIES of hypertensives have been shown to be thicker and stiffer than normal vessels in both experimental animals' 4 and in human subjects.5 ,' However, in humans, these observations resulted either from invasive studies of the pressurevolume relationship of the brachial artery in vivo,5 or from the measurements of the thickness of the aorta at autopsy.6 Little information is available for intact large arteries, probably because of lack of appropriate techniques.We have developed a pulsed Doppler velocimeter7 12 particularly suitable for determining blood flow in peripheral arteries. In addition to its pulsed emission, the apparatus has an adjustable range-gated time system and a double transducer probe.'2 l With the double transducer probe, the angle of the ultrasound beam relative to the flowing stream of blood can be simply evaluated so that the diameter of the artery can be calculated.12 14 This method has been applied to the determination of the diameter, the blood flow velocity and the volumic flow of the brachial artery in 36 patients with essential hypertension. The measureFrom the
“…Patients with coronary heart failure, cerebrovascular disease or peripheral vascular disease were excluded from the study. Both hypertensives and control subjects were classified according to age into those younger than and those older than 40 In addition to the classic pulsed Doppler method,9 12 the present apparatus (Echovar Doppler pulse, Alvar Electronic) has two main original characteristics: the pulsed emission is associated with an adjustable rangegated time system and a double transducer system provides a bidimensional blood velocity measurement, which considerably minimizes the errors induced by the observation angle between the ultrasonic beam and the vessel axis.…”
SUMMARY Diameter, blood flow velocity and volumic flow of the brachial artery were measured in 36 patients with sustained essential hypertension and compared with 25 normal subjects. Both hypertensives and control subjects were classified according to age into those younger than and those older than 40 years. For the determinations, a pulsed Doppler velocimeter with an adjustable range-gated time system and a double transducer probe was used. With the apparatus, the error in the determination of the angle between the ultrasound beam and the flowing stream of blood was less than 2%. In addition, the overestimation of the arterial diameter due to the sample volume size did not exceed 0.035 ± 0.015 cm. In hypertensives, the diameter of the brachial artery was significantly increased. The value was 0.482 ± 0.013 cm in subjects younger than 40 years and 0.517 ± 0,013 cm in those older than 40 years; in the corresponding controls, the values were 0.422 ± 0.011 cm and 0.436 + 0.013 cm (p < 0.01; p < 0.001). Blood flow velocity was reduced (p < 0.05; p < 0.01) and volumic flow remained within normal ranges. Both in the younger and the older groups, a significant positive correlation was observed between mean arterial pressure and the arterial diameter (r = 0.75; r = 0.60). In hypertensives, i.v. dihydralazine decreased mean arterial pressure from 120 ± 7 to 102 ± 7 mm Hg (p < 0.001). Arterial diameter also significantly decreased (p < 0.01) and returned toward normal. The study demonstrated that the diameter of the brachial artery was significantly increased in sustained essential hypertension and suggested that, with the chronic elevation of blood pressure, the large arteries dilate excessively, contributing to the maintainence of arterial blood flow within normal ranges.LARGE ARTERIES of hypertensives have been shown to be thicker and stiffer than normal vessels in both experimental animals' 4 and in human subjects.5 ,' However, in humans, these observations resulted either from invasive studies of the pressurevolume relationship of the brachial artery in vivo,5 or from the measurements of the thickness of the aorta at autopsy.6 Little information is available for intact large arteries, probably because of lack of appropriate techniques.We have developed a pulsed Doppler velocimeter7 12 particularly suitable for determining blood flow in peripheral arteries. In addition to its pulsed emission, the apparatus has an adjustable range-gated time system and a double transducer probe.'2 l With the double transducer probe, the angle of the ultrasound beam relative to the flowing stream of blood can be simply evaluated so that the diameter of the artery can be calculated.12 14 This method has been applied to the determination of the diameter, the blood flow velocity and the volumic flow of the brachial artery in 36 patients with essential hypertension. The measureFrom the
“…Rushmer [30] is among the first American investigators who worked on Doppler techniques along with Baker. Peronneau [31] and Kalmanson [32] from France investigated extensively on the use of Doppler ultrasound for the cardiovascular reasons. Then subsequently Holen [33] and Hatle [34] introduced Doppler ultrasound as a hemodynamic tool, and showed that fairly accurate hemodynamic data could be obtained by this technique.…”
“…Lindström & Edler (1969) presented clinical results. Péronneau described Pulsed Doppler where it became possible to select blood velocity measurement at a given depth in 1969 (Péronneau et al. , 1969) and so did Baker (1970).…”
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