1974
DOI: 10.1136/bmj.3.5930.552
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Deaths from Occlusive Arterial Disease in Renal Allograft Recipients

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Cited by 95 publications
(24 citation statements)
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“…Despite potential recovery of some parameters of renal function, especially urinary concentrating ability and ammonia excretion [22], patients with analgesic nephropathy constitute a significant portion of patients undergoing chronic hemodialysis and renal transplantation [12]. In recent reports of the high prevalence of hyperlipidemia and arterial disease (including coronary heart disease) in renal allograft recipients [29,30], it was concluded that the basis for the arterial disease in these patients was probably set in the pretransplan tation period and that the same factors continued to operate following trans plantation. These points serve to emphasize the need to investigate long-term complications of all patients with renal disease and to detect risk factors associated with these complications.…”
Section: Discussionmentioning
confidence: 99%
“…Despite potential recovery of some parameters of renal function, especially urinary concentrating ability and ammonia excretion [22], patients with analgesic nephropathy constitute a significant portion of patients undergoing chronic hemodialysis and renal transplantation [12]. In recent reports of the high prevalence of hyperlipidemia and arterial disease (including coronary heart disease) in renal allograft recipients [29,30], it was concluded that the basis for the arterial disease in these patients was probably set in the pretransplan tation period and that the same factors continued to operate following trans plantation. These points serve to emphasize the need to investigate long-term complications of all patients with renal disease and to detect risk factors associated with these complications.…”
Section: Discussionmentioning
confidence: 99%
“…Thus many patients receive immunosuppression for pro longed periods and the early problems of rejection are replaced by opportunistic infections, accelerated athero sclerosis [2] and perhaps most distressing of all an increased frequency of neoplasia development [3][4][5][6][7]. The majority of these tumours have arisen in the lymphoreticular system or the skin, depending on the geographical of the studies.…”
Section: Introductionmentioning
confidence: 99%
“…Although the precise mechanisms contributing to the cardiovascular disease which limits the survival of both hemodialysis [1,2] and transplant [3] patients are un known, disturbances in lipoprotein metabolism mani fested as hypertriglyceridemia [4], increased very lowdensity lipoprotein (VLDL) levels [5], and reduced con centrations of high-density lipoproteins (HDL) [6,7] are believed to play some role. Two enzymes which play important roles in plasma lipid transport, the tissue en zyme lipoprotein lipase [4,8] estimated in plasma after heparin, and the plasma enzyme lecithin cholesterol acyl transferase (LCAT), have been reported to have reduced activity in renal failure patients [9], Earlier studies of LCAT in these patients suffer from the fact that no attempt was made to assess the effects of dialysis treatment and stabilization of the chronically uremic state on enzyme activity.…”
Section: Introductionmentioning
confidence: 99%