Deaths from natural causes in people with mental illness: A cohort study

Hiroeh, Urara; Kapur, Navneet; Webb, Roger T.; Dunn, Graham; Mortensen, Preben Bo; Appleby, Louis

doi:10.1016/j.jpsychores.2007.09.008

Cited by 45 publications

(71 citation statements)

References 26 publications

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“…Anxiety and depression are associated with increased mortality,12 and are common in patients with PNES 7. We found no evidence of a predictive effect of psychiatric state in our population.…”

Section: Discussioncontrasting

confidence: 70%

Mortality in a cohort of patients with psychogenic non-epileptic seizures

Duncan

Oto

Wainman-Lefley

2012

J Neurol Neurosurg Psychiatry

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Some evidence suggests that psychogenic non-epileptic seizures (PNES) are associated with increased mortality. The authors obtained death certificate information in a cohort of 260 patients who presented with PNES between 1999 and 2004. The follow-up period averaged 7.92 years, during which 17 patients died, 12/17 were under the age of 75 years, giving a premature (<75 years) mortality rate of 0.58%, compared with a Scottish mortality rate for the 40-75 years age group of 0.41% per year. The main predictor of death was the patient age at presentation of PNES. There was no correlation with withdrawal of anticonvulsant medication, and death certificate information provided no evidence to suggest that the deaths were related to the seizure disorder. The population had a high mean deprivation rank, providing a possible explanation for a modest increase in premature death rate.

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Section: Discussioncontrasting

confidence: 70%

Mortality in a cohort of patients with psychogenic non-epileptic seizures

Duncan

Oto

Wainman-Lefley

2012

J Neurol Neurosurg Psychiatry

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“…All types of mental illness are associated with increased mortality from both natural and unnatural causes. [26][27][28] There are substantial differences in excess mortality between types of mental illness: it is highest for anorexia nervosa, 29 very high for schizophrenia, 17,30 autism, 31,32 bipolar disorder 33 and unipolar depression, 34,35 and moderate for anxiety disorders 26,36,37 (Table 1). A large proportion of the excess mortality, especially suicides, occurs at young age and thus shortens the reproductive period.…”

Section: The Building Blocksmentioning

confidence: 99%

The role of genetic variation in the causation of mental illness: an evolution-informed framework

2009

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“…In most cases, these are limited to people who have received inpatient treatment for mental illness. 10 For instance, Hiroeh et al 11 followed up a population of 4.1 million people of whom 258 000 (6%) had received inpatient treatment for psychiatric illness. Mortality rates were elevated for all psychiatric diagnoses, with highest risks observed for organic psychoses, dementia, and drug and alcohol abuse (SMRs around 3).…”

Section: Excess Mortality By Settingmentioning

confidence: 99%

The Epidemiology of Excess Mortality in People with Mental Illness

2010

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T he excess mortality of people with mental illness has been known for many years. In 1841, William Farr 1 reported to the Royal Statistical Society on mortality within the major asylums and licensed houses of the period in England. He estimated, using life-table methods, the mortality rate in the best facility to be about 3 times that of the general population, and mortality in other facilities to be several times higher again. The report inspired the British parliament to require regular compilation of statistics within all asylums, and established mortality rate as a measure of the quality of care provided. The high mortality was attributed to infectious diseases and the poor conditions within the asylums, such as lack of exercise and warmth, poor diet, and lack of medical care. During subsequent years, mortality in people with mental illness has been the subject of hundreds of studies. In the most comprehensive meta-analyses to date, Harris and Barraclough 2,3 identified 152 reports on all-cause mortality and 249 on suicide. They found that all mental disorders were associated with an increased risk of premature death. Overall

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Deaths from natural causes in people with mental illness: A cohort study

Cited by 45 publications

References 26 publications

Mortality in a cohort of patients with psychogenic non-epileptic seizures

Mortality in a cohort of patients with psychogenic non-epileptic seizures

The role of genetic variation in the causation of mental illness: an evolution-informed framework

The Epidemiology of Excess Mortality in People with Mental Illness

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