Death within 30 days of fine needle aspiration: Post‐mortem confirmation of FNA diagnoses and the contribution of FNA to patient mortality

Priemer, David S.; Berry, William A.; Hawley, Dean A.; Cramer, Harvey

doi:10.1002/dc.23985

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…This is a consideration for future studies. Unsurprisingly, the overall discrepancy rate of 13% in liver, lung, and kidney biopsies in this study is smaller than the overall discrepancy rate of 27% between FNA diagnoses and autopsy findings highlighted by another recent study [ 20 ]. Regardless, however, our data further highlight the diagnostic discrepancies that continue to exist between pre- and post-mortem diagnoses in modern medicine.…”

Section: Discussioncontrasting

confidence: 85%

Concordance of Solid Organ Biopsy Diagnoses With Hospital Autopsy and the Contribution of Biopsies to Death

Priemer¹,

Curran²,

Phillips³

et al. 2023

Cureus

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Biopsies of the liver, lung, and kidney are performed for many indications, including organ dysfunction, mass lesions, and allograft monitoring. The diagnosis depends on the sample, which may or may not be representative of the lesion or pathology in question. Further, biopsies are not without risk of complications. Autopsies are a resource for assessing the accuracy of biopsy diagnoses and evaluating possible complications. Herein, we aimed to compare liver, lung, and kidney biopsy diagnoses with those from autopsies conducted soon after the procedure and to assess the contribution of biopsy to mortality. A 28year search of our database identified 147 patients who were autopsied after dying within 30 days of a liver, lung, or kidney biopsy. The concordance of the biopsy diagnosis with the autopsy findings was determined. Finally, medical records were reviewed to determine the likelihood that a biopsy contributed to the patient's death. The contribution of the biopsy to death was categorized as "unlikely," "possible," or "probable." Overall concordance between biopsy and autopsy diagnoses was 87% (128/147), including 95% (87/92), 71% (32/45), and 90% (9/10) for liver, lung, and kidney biopsies, respectively. Concordance was lower for biopsies of suspected neoplasms versus non-neoplastic diseases. Lung biopsy concordance was higher for wedge biopsy versus needle or forceps biopsy. A biopsy was determined to at least "possibly" contribute to death in 23 cases (16%). In conclusion, an autopsy is an important tool to validate liver, lung, or kidney biopsy diagnoses. Confirmation of biopsy diagnoses via post-mortem examination may be particularly valuable when patients die soon after the biopsy procedure. Furthermore, an autopsy is especially useful when patients die soon after a biopsy in order to determine what role, if any, the procedure played in their deaths. Though biopsy complications are uncommon, a biopsy may still contribute to or precipitate death in a small number of patients.

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Section: Discussioncontrasting

confidence: 85%

Concordance of Solid Organ Biopsy Diagnoses With Hospital Autopsy and the Contribution of Biopsies to Death

Priemer¹,

Curran²,

Phillips³

et al. 2023

Cureus

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Overview of Pathologic Findings of Vaping in the Context of an Autopsy Patient With Chronic Injury

Priemer

Gravenmier

Batouli

et al. 2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Electronic cigarettes are handheld devices that heat an inner liquid containing chemicals to be aerosolized and inhaled, and have become a popular alternative to conventional cigarettes. Their use, termed vaping, has been linked to severe injury, with 2711 cases of associated lung injury and 60 deaths reported to the Centers for Disease Control and Prevention at time of writing. Published case reports and series have emerged detailing clinical and imaging characteristics of vaping-induced lung injury. However, the pathologic characteristics of these induced injuries are still being established, particularly findings occurring over time. Objective.— To illustrate the autopsy findings of an older patient who died of vaping-induced injury after prolonged symptomology and to provide a review of the most recent literature regarding the basic science, epidemiology, clinical presentation, imaging characteristics, and pathology of vaping-induced lung injury. Data Sources.— Autopsy case and peer-reviewed literature. Conclusions.— Vaping-induced lung injury has emerged as a public health issue, and this case represents a rare opportunity to evaluate this issue at autopsy. Most commonly, the injury has been attributed to tetrahydrocannabinol product use as opposed to nicotine. This case demonstrates that as today's young and relatively healthy vapers grow older and develop the comorbidities that come with advanced age, there is serious risk of chronic lung damage from vaping that could result in death. Further observations and studies, particularly autopsy evidence, are clearly important to understand the possible outcomes.

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Death within 30 days of fine needle aspiration: Post‐mortem confirmation of FNA diagnoses and the contribution of FNA to patient mortality

Cited by 2 publications

References 34 publications

Concordance of Solid Organ Biopsy Diagnoses With Hospital Autopsy and the Contribution of Biopsies to Death

Concordance of Solid Organ Biopsy Diagnoses With Hospital Autopsy and the Contribution of Biopsies to Death

Overview of Pathologic Findings of Vaping in the Context of an Autopsy Patient With Chronic Injury

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