Death receptor 3 is involved in preeclampsia through regulating placental trophoblast cell physiology by inactivating the PI3K/AKT pathway
Cheng Yin,
Jiahui Wang,
Yu Zhang
et al.
Abstract:BackgroundPreeclampsia (PE) is a pregnancy related disease that affects about 5% of pregnancies. Death receptor 3 (DR3) expression is significantly elevated in both placental tissue and plasma of PE patients. However, whether DR3 was involved in trophoblasts in pathogenesis of PE are not well elucidated.ObjectiveOur research was designed to illustrate the biological roles of DR3 in placental trophoblasts, as well as explain its relevant mechanisms.MethodsHTR‐8/SVneo cells viability, migration, invasion, and ap… Show more
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