OBJECTIVE: To identify risk factors for death among patients with severe asthma. METHODS: This was a nested case-control study. Among the patients with severe asthma
treated between December of 2002 and December of 2010 at the Central Referral
Outpatient Clinic of the Bahia State Asthma Control Program, in the city of
Salvador, Brazil, we selected all those who died, as well as selecting other
patients with severe asthma to be used as controls (at a ratio of 1:4). Data were
collected from the medical charts of the patients, home visit reports, and death
certificates. RESULTS: We selected 58 cases of deaths and 232 control cases. Most of the deaths were
attributed to respiratory causes and occurred within a health care facility.
Advanced age, unemployment, rhinitis, symptoms of gastroesophageal reflux disease,
long-standing asthma, and persistent airflow obstruction were common features in
both groups. Multivariate analysis showed that male gender, FEV1
pre-bronchodilator < 60% of predicted, and the lack of control of asthma
symptoms were significantly and independently associated with mortality in this
sample of patients with severe asthma. CONCLUSIONS: In this cohort of outpatients with severe asthma, the deaths occurred
predominantly due to respiratory causes and within a health care facility. Lack of
asthma control and male gender were risk factors for mortality.