Dearomative <i>gem</i>-diprenylation of hydroxynaphthalenes by an engineered fungal prenyltransferase

Xu, Yuanyuan; Li, Dan; Wang, Wenxuan; Xu, Kang‐Ping; Tan, Gui‐Shan; Li, Jing; Li, Shu‐Ming; Yu, Xia

doi:10.1039/d2ra04837j

RSC Adv.

2022

DOI: 10.1039/d2ra04837j

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Dearomative gem-diprenylation of hydroxynaphthalenes by an engineered fungal prenyltransferase

Yuanyuan Xu

Dan Li

Wenxuan Wang

et al.

Abstract: A new catalyst for regiospecific dearomative gem-diprenylation of α-hydroxynaphthalenes from the F253G mutant of the fungal prenyltransferase CdpC3PT.

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Cited by 2 publications

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A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors

Martin,

Dierlamm,

Zocher

et al. 2023

Appl Microbiol Biotechnol

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The fungal prenyltransferase ShPT from Stereum hirsutum was believed to prenylate 4-hydroxybenzyl alcohol and thereby be involved in the vibralactone biosynthesis. In this study, we demonstrate that hydroxynaphthalenes instead of benzyl alcohol or aldehyde were accepted by ShPT for regular C-prenylation in the presence of both dimethylallyl and geranyl diphosphate. Although the natural substrate of ShPT remains unknown, our results provide one additional prenyltransferase from basidiomycetes, which are less studied, in comparison to those from other sources. Furthermore, this study expands the chemical toolbox for regioselective production of prenylated naphthalene derivatives. Key points •Basidiomycetous prenyltransferase •Biochemical characterization •A DMATS prenyltransferase prenylating hydroxynaphthalene derivatives

show abstract

A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors

Martin,

Dierlamm,

Zocher

et al. 2023

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

show abstract

Ligand-controlled regiodivergence in Pd-catalyzed coupling of azlactones with isoprene

Zhang,

Hu,

Liu

et al. 2024

Cell Reports Physical Science

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Dearomative gem-diprenylation of hydroxynaphthalenes by an engineered fungal prenyltransferase

Abstract: A new catalyst for regiospecific dearomative gem-diprenylation of α-hydroxynaphthalenes from the F253G mutant of the fungal prenyltransferase CdpC3PT.

Cited by 2 publications

References 21 publications

A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors

A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors

Ligand-controlled regiodivergence in Pd-catalyzed coupling of azlactones with isoprene

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