The issue of design for social innovation is closely linked to citizen participation and the inclusion of the different groups that make up society, particularly the most disadvantaged or at risk of being marginalized. The new product and service design paradigm requires a specific sensitivity in which education and research have to be combined to produce sustainable innovation. A key aspect in the future of design will be cross-disciplinary knowledge and disciplines more adapted to local needs and specific user groups. Hence, as a matter of constructing the future, it seems that the business model has to be re-invented in collaboration with all stakeholders. This chapter gives a sample of the innovation processes experienced in the EPS program, which reflect the interrelationship between open and participatory design methods linked to the issues of accessibility and inclusion in different contexts.