Deagglomeration and characterization of detonation nanodiamonds for biomedical applications

Pedroso‐Santana, Seidy; Sarabia‐Sainz, Andre‐í; Fleitas‐Salazar, Noralvis; Santacruz-Gómez, Karla; Acosta-Elías, Mónica; Pedroza‐Montero, M.; Riera, R.

doi:10.1016/j.jab.2016.09.003

Cited by 21 publications

(16 citation statements)

References 22 publications

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“…Therefore, to best use the features of NDs as fillers for polymers such as PMMA, it is imperative that the nanoparticles are highly uniformly dispersed. However, due to the surface chemistry of ND, deagglomeration beyond the microscale with simple mechanical methods alone is challenging; hence, surface modification is required [ 25 ]. Surface functionalization of the ND can aid the deagglomeration process and improve stability in organic media by reducing the surface energy and inter-particle bonding of nanoparticles [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Incorporating Aminated Nanodiamonds to Improve the Mechanical Properties of 3D-Printed Resin-Based Biomedical Appliances

Mangal

Seo

et al. 2020

Nanomaterials

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The creation of clinically patient-specific 3D-printed biomedical appliances that can withstand the physical stresses of the complex biological environment is an important objective. To that end, this study aimed to evaluate the efficacy of aminated nanodiamonds (A-NDs) as nanofillers in biological-grade acrylate-based 3D-printed materials. Solution-based mixing was used to incorporate 0.1 wt% purified nanodiamond (NDs) and A-NDs into UV-polymerized poly(methyl methacrylate) (PMMA). The ND and A-ND nanocomposites showed significantly lower water contact angles (p < 0.001) and solubilities (p < 0.05) compared to those of the control. Both nanocomposites showed markedly improved mechanical properties, with the A-ND-containing nanocomposite showing a statistically significant increase in the flexural strength (p < 0.001), elastic modulus (p < 0.01), and impact strength (p < 0.001) compared to the control and ND-containing groups. The Vickers hardness and wear-resistance values of the A-ND-incorporated material were significantly higher (p < 0.001) than those of the control and were comparable to the values observed for the ND-containing group. In addition, trueness analysis was used to verify that 3D-printed orthodontic brackets prepared with the A-ND- and ND-nanocomposites exhibited no significant differences in accuracy. Hence, we conclude that the successful incorporation of 0.1 wt% A-ND in UV-polymerized PMMA resin significantly improves the mechanical properties of the resin for the additive manufacturing of precisive 3D-printed biomedical appliances.

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Section: Discussionmentioning

confidence: 99%

Incorporating Aminated Nanodiamonds to Improve the Mechanical Properties of 3D-Printed Resin-Based Biomedical Appliances

Mangal

Seo

et al. 2020

Nanomaterials

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“…Complementary studies to determine the hemotoxic activity of all nanoparticle samples, the RBCs viability assay were tested [44]. Trypan blue was used to estimate the number of viable RBCs by counting intact cells that have not been stained with trypan dye under the microscope [45] (Figure Complementary studies to determine the hemotoxic activity of all nanoparticle samples, the RBCs viability assay were tested [44]. Trypan blue was used to estimate the number of viable RBCs by counting intact cells that have not been stained with trypan dye under the microscope [45] (Figure 4).…”

Section: Hemolysis Assay and Rbcs Viability Assaymentioning

confidence: 99%

“…Trypan blue was used to estimate the number of viable RBCs by counting intact cells that have not been stained with trypan dye under the microscope [45] (Figure Complementary studies to determine the hemotoxic activity of all nanoparticle samples, the RBCs viability assay were tested [44]. Trypan blue was used to estimate the number of viable RBCs by counting intact cells that have not been stained with trypan dye under the microscope [45] (Figure 4). All nanoparticles' results showed almost 100% cell viability (<2% loss of membrane continuity).…”

Section: Hemolysis Assay and Rbcs Viability Assaymentioning

confidence: 99%

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Albumin-Albumin/Lactosylated Core-Shell Nanoparticles: Therapy to Treat Hepatocellular Carcinoma for Controlled Delivery of Doxorubicin

et al. 2020

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Doxorubicin (Dox) is the most widely used chemotherapeutic agent and is considered a highly powerful and broad-spectrum for cancer treatment. However, its application is compromised by the cumulative side effect of dose-dependent cardiotoxicity. Because of this, targeted drug delivery systems (DDS) are currently being explored in an attempt to reduce Dox systemic side-effects. In this study, DDS targeting hepatocellular carcinoma (HCC) has been designed, specifically to the asialoglycoprotein receptor (ASGPR). Dox-loaded albumin-albumin/lactosylated (core-shell) nanoparticles (tBSA/BSALac NPs) with low (LC) and high (HC) crosslink using glutaraldehyde were synthesized. Nanoparticles presented spherical shapes with a size distribution of 257 ± 14 nm and 254 ± 14 nm, as well as an estimated surface charge of −28.0 ± 0.1 mV and −26.0 ± 0.2 mV, respectively. The encapsulation efficiency of Dox for the two types of nanoparticles was higher than 80%. The in vitro drug release results showed a sustained and controlled release profile. Additionally, the nanoparticles were revealed to be biocompatible with red blood cells (RBCs) and human liver cancer cells (HepG2 cells). In cytotoxicity assays, Dox-loaded nanoparticles decrease cell viability more efficiently than free Dox. Specific biorecognition assays confirmed the interaction between nanoparticles and HepG2 cells, especially with ASGPRs. Both types of nanoparticles may be possible DDS specifically targeting HCC, thus reducing side effects, mainly cardiotoxicity. Therefore, improving the quality of life from patients during chemotherapy.

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“…Researchers have used carboxylation, hydrogenation, ammoniation, hydroxylation, and surface oxidation to form some chemical functional groups on the surface of NDs. Pedroso-Santana et al 11 used bead-assisted sonic disintegration and carboxylation procedures. In an aqueous suspension, the aggregate size of diamond is reduced from greater than 1 mm to approximately 100 nm.…”

Section: Introductionmentioning

confidence: 99%

Microstructure and mechanical properties of aluminum matrix composites with different volume fractions of surface-oxidized nanodiamonds

Wei

Kang

et al. 2020

Advanced Composites Letters

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Nanodiamonds (NDs) have the characteristics of both diamonds and nanomaterials. However, it is difficult to disperse NDs, and this is why there is less research regarding NDs in the field of aluminum matrix composites. In the present work, NDs were modified via surface oxidation, and ND/Al matrix composites were successfully prepared via mechanical ball milling and vacuum sintering. The effects of different volume fraction of NDs (1%, 3%, 5%, 7%) after surface oxidation on the ND/Al matrix composite were analyzed using a metallographic microscope, scanning electron microscope, infrared spectrometer, X-ray diffractometer, microhardness tester, and universal testing machine. The results show that the optimal temperature of surface oxidation treatment is 673 K, which effectively purifies the surface of ND and introduces appropriate C=O functional groups. NDs are uniformly distributed in the aluminum matrix, and no harmful Al4C3 phase is formed. With an increase in the volume fraction of NDs, the grain size of the matrix first decreases and then increases, and the ultimate compressive strength first increases and then decreases. The volume fraction of ND with better comprehensive performance is 3% and the yield strength increased by 19%.

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Deagglomeration and characterization of detonation nanodiamonds for biomedical applications

Cited by 21 publications

References 22 publications

Incorporating Aminated Nanodiamonds to Improve the Mechanical Properties of 3D-Printed Resin-Based Biomedical Appliances

Incorporating Aminated Nanodiamonds to Improve the Mechanical Properties of 3D-Printed Resin-Based Biomedical Appliances

Albumin-Albumin/Lactosylated Core-Shell Nanoparticles: Therapy to Treat Hepatocellular Carcinoma for Controlled Delivery of Doxorubicin

Microstructure and mechanical properties of aluminum matrix composites with different volume fractions of surface-oxidized nanodiamonds

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