Deafferentation–disconnection neglect induced by posterior cerebral artery infarction

Park, K. C.; Lee, B. H.; Kim, E. J.; Shin, Minho; Choi, Kyung Mook; Yoon, Sung Sang; Kwon, Sun U.; Chung, Chin‐Sang; Lee, K. H.; Heilman, Kenneth M.; Na, D. L.

doi:10.1212/01.wnl.0000191306.67582.7a

Cited by 57 publications

(28 citation statements)

References 40 publications

(58 reference statements)

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“…Whereas previous study indicated that occipital lesions are rarely linked to HN [31], more recent studies show that HN occurs frequently [19] in patients with lesions in the occipital area when combined with other areas supplied by PCA [19,32] or in patients with parahippocampal gyrus lesions [5]. …”

Section: Discussionmentioning

confidence: 99%

“…None of the patients had any lesion in the left hemisphere. Three patients with lesions in the splenium that appeared in at least 2 axial slices were excluded because complete splenium lesions can result in HN by the disconnection mechanism [19]. The final sample was 42 patients (30 males and 12 females) with a mean age of 61.2 ± 13.2 years and a mean education of 10.3 ± 4.7 years.…”

Section: Methodsmentioning

confidence: 99%

“…The structural lesions visually identified on CT (n = 4) or MRI (n = 38, diffusion and T2) were outlined in each section using a manual pixel-wise method with the aid of PACS workstation (General Electric) to measure the lesion volume in cm 3 [19,21]. For lesion location analyses, lesions on CT or MRI were manually drawn on the standard T1-weighted MRI templates provided by MRIcro (http://www.mricro.com).…”

Section: Methodsmentioning

confidence: 99%

“…The battery included 3 line bisection tasks (a solid line bisection test, 2 tests from the Character Line Bisection Task: the Letter Line Bisection and Star-Line Bisection) [21], 2 cancellation tasks (a modified version of Albert’s line cancellation test and the Star cancellation task) and the sum of the 2-figure copying tasks (the modified Ogden Scene and the Two Daisy figure). This battery, including the Character Line Bisection Task and the conventional neglect tests, was demonstrated to be reliable and valid, and details on administration and scoring method have been previously described [19,21]. Briefly, for Letter-line and Star-line bisection, the patients were instructed to look at a linear array of different characters and circle a target character (letter or star) that is closest to the middle.The total neglect score (maximum score 57) was converted to a 100-point scale by the following formula: the patient’s total score of completed tasks divided by the possible maximum score of completed tasks ×100.…”

Section: Methodsmentioning

confidence: 99%

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Neural Correlates of Hemispatial Neglect: A Voxel-Based SPECT Study

et al. 2010

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Background: Despite many studies that investigated the neural correlates of hemispatial neglect (HN) with structural imaging, studies using voxel-wise analyses of functional imaging are not available. Furthermore, previous studies neither considered the neglect severity nor investigated whether there are differences in these neural correlates according to each neglect subtest. This study aimed to investigate the neural correlates of HN by correlating the total and the individual neglect score with hypoperfusion value on single photon emission computed tomography (SPECT) using voxel-wise analyses. Methods: Forty-two patients with acute right hemisphere strokes underwent a neglect test battery consisting of 3 bisection tasks, 2 cancellation tasks and 2 copying tasks. The SPECT images were acquired in these patients and 10 age- and education-matched normal controls. Results: Patients with HN, compared to those without HN, had hypoperfusion in the right middle temporal-occipital junction, inferior frontal gyrus and retrosplenial area. The total neglect score correlated with the hypoperfusion in the right middle temporal-occipital junction, fusiform gyrus, parahippocampal gyrus, inferior temporal gyrus, anterior part of the superior and middle temporal gyri, cuneus, lingual gyrus, angular gyrus, and the cerebellum. Across the neglect subtests similar correlation patterns were observed with minor variations. Conclusions: Unlike the results of previous studies showing that the critical neural correlates for HN are inferior parietal lobule or superior temporal gyrus, our study showed that the lesions that critically contribute to the neglect severity were located in the posterior parts of the middle temporal gyrus (temporal-occipital junction).

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Neural Correlates of Hemispatial Neglect: A Voxel-Based SPECT Study

et al. 2010

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“…In such tasks, right hippocampus is expected to play a bigger role but left hippocampal structures are also known to be activated (9). Similarly, left PCA infarctions may produce visuospatial deficits similar to right PCA lesions, but possibly with less severity (10).…”

Section: Discussionmentioning

confidence: 99%

Bilişsel Bulgularıyla PSA Enfarktı: Hemianopsiden Fazlası

Bozdoğan¹,

Sağ²,

Öztekin³

et al. 2013

Tnd

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Posterior cerebral artery infarctions constitute 5-10% of all ischemic strokes. The case of a 62 year-old man presenting with right hemiparesia and dysarthria is discussed in this article. The patient had acute onset demential symptoms and difficulty in reading, and an acute infarction in the territory of left posterior cerebral artery was detected in cranial magnetic resonance imaging. The patient who had acute ischemic lesions in left parahippocampus, splenium of corpus callosum, left fusiform gyrus and left thalamus was evaluated with detailed neuropsychological tests. Cognitive deficits severe enough to affect daily living were detected. Pure alexia, anterograde amnesia and anomia, being often neglected manifestations of unilateral posterior cerebral artery infarction, are going to be reviewed with relevant radiological findings. (Turkish Journal of Neurology 2013; 19:139-142) ÖzetArteria cerebri posterior infarktları tüm iskemik inmelerin %5-10'unu oluşturur. Bu yazıda sağ hemiparezi ve konuşma bozukluğu yakınmasıyla başvuran 62 yaşında bir erkek olgu sunulacaktır. Hastada bu olayla birlikte başlayan demans bulguları ve okuma bozukluğu gözlenmiş olup beyin manyetik rezonans görüntülemesinde sol posterior serebral arter sulama alanına denk gelen akut infarkt tespit edilmiştir. Sol parahipokampüste, korpus kallozumun splenium kesiminde, sol fusiform girusta ve sol talamusta akut iskemik lezyonları olan hastaya erken dönemde detaylı nöropsikolojik testler uygulanmış ve günlük yaşantısını etkileyecek boyutta bilişsel bozukluklarının ortaya çıktığı tespit edilmiştir. Tek taraflı posterior serebral arter infarktının günlük uygulamada çoğunlukla ihmal ettiğimiz bulguları olan saf aleksi, anterograd amnezi ve anomi radyolojik bulgular eşliğinde tartışılacaktır. (Türk Nöroloji Dergisi 2013; 19:139-142) Anah tar Ke li me ler: Aleksi, anomi, amnezi, posterior serebral arter

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Alien limb following posterior cerebral artery stroke: Failure to recognize internally generated movements?

2007

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We describe two rare cases of alien limb syndrome following right posterior cerebral artery (PCA) stroke. Both patients present with left hemianopia, visual neglect and proprioceptive loss in addition to their alien limb symptoms. Lesion subtraction from seven control PCA patients revealed that medial parietal-occipital and thalamic areas were selectively damaged in the alien limb patients. We propose that loss of the sense of motor intention and internal model of the current state of the arm, combined with deficient proprioceptive and visual feedback of the moving limb, are critical for genesis of posterior alien limb and discuss how affected regions normally function to ensure awareness of self-generated motor activity.

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Deafferentation–disconnection neglect induced by posterior cerebral artery infarction

Cited by 57 publications

References 40 publications

Neural Correlates of Hemispatial Neglect: A Voxel-Based SPECT Study

Neural Correlates of Hemispatial Neglect: A Voxel-Based SPECT Study

Bilişsel Bulgularıyla PSA Enfarktı: Hemianopsiden Fazlası

Alien limb following posterior cerebral artery stroke: Failure to recognize internally generated movements?

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