“…In order to maintain this constraint, we reserve all the cells around a droplet creating a bound box of size 3 × 3. The droplet occupies the center of the bound box and all other eight cells around it is treated as blockages,so that no other droplet can occupy it [3], [5], [11]. Mathematically droplet routing problem can be defined as Input: A m×n biochip with B blockages, a set of k droplets D. Each droplet D i , have a source cell (X s i ,X s i ) and a destination cell (X d i ,Y d i ) where i ≤k.…”