In this paper, we propose a new priority multi-objective optimization strategy of system output variables in cutting tobacco process. The proposed strategy focuses on the cutting tobacco moisture-controlled output variables optimization in feasible regions with two levels according to the priority. This study aims to provide a novel technical support for the chemical industry contained drying process. In order to alleviate the lack of degree of freedom of the system, strict set-point control is given, meanwhile, other output variables adopt zone control. Firstly, the system control output variables are optimized in ascending order of priority. Secondly, the specific lower-level target constraints are first relaxed. Finally, the relaxation of other high-priority target constraints is stopped when the optimization is feasible. Thus, the system control output variables move along the optimal target trajectory. From the perspective of practical application of engineering, under the condition of disturbance existing in the cutting tobacco drying process, the simulation shows that the proposed approach has good robustness when there is disturbance, and the previous method cannot meet the control requirement. The proposed strategy meanwhile has better tracking effect through single and multiple output variables simulation, which compared with traditional predictive control in real cutting tobacco drying process.