“…Moreover, HDACs, and particularly HDAC2, seem to have important roles in the inflammatory responses associated with COPD 11,17,18 . Furthermore, because corticosteroids use HDAC2 to suppress the activity of NF-kB 11,12,19 , the inhibitory effect of CS on HDAC2 may be responsible for the reduced sensitivity of COPD patients to steroid treatment 11 . Therefore, compounds that activate HDAC2 or inhibit ROS production and NF-kB may be effective for the treatment of inflammation associated with COPD.…”