Deacetyl-thymosin .BETA.4: Synthesis and effect on the impaired peripheral T-cell subsets in patients with chronic renal failure.

Functional roles of Phe12 of deacetyl‐thymosin β4 in the impaired blastogenic response of uraemic T‐lymphocytes

“…We also noticed that the acetyl group at the N-terminal serine residue of thymosin b 4 , is not required for the restorative effect on the impaired cell-mediated immunological functions. 5 In an earlier paper, 8 we reported that the synthetic [Phe(4F) 12 ]deacetyl-thymosin b 4 exhibited stronger restorative effect on the impaired blastogenic response of T-lymphocytes isolated from uraemic patients than that of our synthetic deacetyl-thymosin b 4 . In this study, the strong electron-withdrawing uoride atom on the para-position of the aromatic ring results in an analogue that possesses stronger activity than that of the parent molecule.…”

Syntheses of two deacetyl‐thymosin β4 analogs and their anti‐inflammatory effect on carrageenin‐induced edema in the mouse paw

“…In our preceding paper, 3 we reported that Phe 12 residue of deacetyl-thymosin b 4 is one of the struc-tural essentials for immunological activity on the impaired blastogenic response of uremic T lymphocytes. One of our synthetic analogs, 3,4 [Phe(4F) 12 ]deacetyl-thymosin b 4 , exhibited stronger immunological activity than that of our synthetic deacetyl-thymosin carrageenin-induced edema in the mouse paw is presented in Table 3. Interestingly, our synthetic [Met(0) 6 , Phe(4F) 12 ]deacetyl-thymosin b 4 showed stronger anti-inflammatory activity than that of our synthetic [Met(0) 6 ]deacetyl-thymosin b 4 .…”

“…In our preceding paper, 3 we concluded that the acetyl group at the N-terminal Ser residue of thymo-sin b 4 is not required for immunological activity. We have also reported 4 that our synthetic [Phe(4F) 12 ] deacetyl-thymosin b 4 (Phe(4F), para-fluorophenylalanine) which has the strong electron-withdrawing fluoride atom on the para position of the aromatic ring of deacetyl-thymosin b 4 , showed stronger immunological activity than that of our synthetic deacetyl-thymosin b 4 .…”

Thymic hormones ? A clinical update

“…TH appear to be effective in improving the immune status in animals affected by several of these diseases. No effect was observed in normal individuals [1]. Furthermore, it has recently been reported that thymosin 134" was able to increase in vitro to almost normal levels the percentage of helper T cells (OKT4+ cells) and all peripheral T cells (OKT3 + cells) without changing the percentage of suppressor T cells (OKTS+ cells) in patients with chronic renal failure [1].…”