De-SUMOylation of CCCTC Binding Factor (CTCF) in Hypoxic Stress-induced Human Corneal Epithelial Cells

Wang, Jie; Wang, Yumei; Lu, Luo

doi:10.1074/jbc.m111.286641

Cited by 31 publications

(23 citation statements)

References 47 publications

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“…In fact, CTCF can be activated by other proliferative signaling pathways as well, such as the Erk pathway (15). In addition, at a posttranslational level, it has been shown that CTCF is also a target protein subject to modifications of SUMOylation and phosphorylation (40).…”

Section: Discussionmentioning

confidence: 99%

Epidermal Growth Factor (EGF)-induced Corneal Epithelial Wound Healing through Nuclear Factor κB Subtype-regulated CCCTC Binding Factor (CTCF) Activation

Wang

Shi

et al. 2013

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

Epidermal Growth Factor (EGF)-induced Corneal Epithelial Wound Healing through Nuclear Factor κB Subtype-regulated CCCTC Binding Factor (CTCF) Activation

Wang

Shi

et al. 2013

Journal of Biological Chemistry

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“…Oxidative stress activated Bcl3, which in turn suppressed the expression of CTCF through a noncanonical NF- κ B pathway [212, 213]. Recent evidence indicates that hypoxic stress induces de-SUMOylation of CTCF to functionally regulate its activity [214]. …”

Section: Transcription Factors Regulating Ocular Surface Developmentmentioning

confidence: 99%

Ocular Surface Development and Gene Expression

Swamynathan

2013

Journal of Ophthalmology

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The ocular surface—a continuous epithelial surface with regional specializations including the surface and glandular epithelia of the cornea, conjunctiva, and lacrimal and meibomian glands connected by the overlying tear film—plays a central role in vision. Molecular and cellular events involved in embryonic development, postnatal maturation, and maintenance of the ocular surface are precisely regulated at the level of gene expression by a well-coordinated network of transcription factors. A thorough appreciation of the biological characteristics of the ocular surface in terms of its gene expression profiles and their regulation provides us with a valuable insight into the pathophysiology of various blinding disorders that disrupt the normal development, maturation, and/or maintenance of the ocular surface. This paper summarizes the current status of our knowledge related to the ocular surface development and gene expression and the contribution of different transcription factors to this process.

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“…Protein arginine methyltransferase 2 (PRMT2) is increased in mice exposed to hypoxia . In human corneal epithelial cells, de‐SUMOylation of CCCTC binding factor (CTCF, an epigenetic factor) is induced by hypoxia . Interaction between HIF‐1α and KDM3A mediates the expression of Glut3 gene in HUVEC cells …”

Section: Proteins Mediating Histone Modifications Involved In Hypoxiamentioning

confidence: 99%

Epigenetic regulation of hypoxia‐responsive gene expression: Focusing on chromatin and DNA modifications

Tsai¹,

2013

Intl Journal of Cancer

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Mammalian cells constantly encounter hypoxia, which is a stress condition occurring during development and physiological processes. To adapt to this inevitable condition, cells develop various mechanisms to cope with this stress and survive. In addition to the activation/stabilization of transcriptional regulators (hypoxia-inducible factors), other epigenetic mechanisms of gene regulation are used. These mechanisms are mediated by various players including transcriptional coregulators, chromatin-modifying complexes, histone modification enzymes and changes in DNA methylation status. Recent progress in all the fields mentioned above has greatly improved the knowledge of how gene regulation contributes to the hypoxic response. This review should shed light on the molecular epigenetic mechanisms of hypoxia-induced gene regulation and help understand the processes adapted by cells to cope with hypoxia.Insufficient oxygen availability, or hypoxia, is a microenvironmental factor that plays a critical role in various biological processes including development, metabolism, inflammation, tumor progression and cancer stemness.

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De-SUMOylation of CCCTC Binding Factor (CTCF) in Hypoxic Stress-induced Human Corneal Epithelial Cells

Cited by 31 publications

References 47 publications

Epidermal Growth Factor (EGF)-induced Corneal Epithelial Wound Healing through Nuclear Factor κB Subtype-regulated CCCTC Binding Factor (CTCF) Activation

Epidermal Growth Factor (EGF)-induced Corneal Epithelial Wound Healing through Nuclear Factor κB Subtype-regulated CCCTC Binding Factor (CTCF) Activation

Ocular Surface Development and Gene Expression

Epigenetic regulation of hypoxia‐responsive gene expression: Focusing on chromatin and DNA modifications

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