De novo Vessel Formation Through Cross-Talk of Blood-Derived Cells and Mesenchymal Stromal Cells in the Absence of Pre-existing Vascular Structures

Rüger, Beate M.; Buchacher, Tanja; Dauber, E.M.; Pasztorek, Markus; Uhrín, Pavel; Fischer, Michael B.; Breuss, Johannes M.; Leitner, Gerda

doi:10.3389/fbioe.2020.602210

Cited by 8 publications

(7 citation statements)

References 78 publications

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“…Pericytes are important pericytes supporting capillaries. 49 Reduced pericyte coverage in the endodermis can lead to vascular loss. In pulmonary arterial hypertension (PAH), the expression of FZD genes required for WNT/PCP activation in the pericyte is reduced, which is an essential mechanism for EC motility and polarity.…”

Section: Role Of Wnt In the Cardiovascular Systemmentioning

confidence: 99%

Roles of Wnt Signaling Pathway and ROR2 Receptor in Embryonic Development: An Update Review Article

Guo

Xing

2022

Genet Epigenet

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The Wnt family is a large class of highly conserved cysteine-rich secretory glycoproteins that play a vital role in various cellular and physiological courses through different signaling pathways during embryogenesis and tissue homeostasis 3. Wnt5a is a secreted glycoprotein that belongs to the noncanonical Wnt family and is involved in a wide range of developmental and tissue homeostasis. A growing body of evidence suggests that Wnt5a affects embryonic development, signaling through various receptors, starting with the activation of β-catenin by Wnt5a. In addition to affecting planar cell polarity and Ca2+ pathways, β-catenin also includes multiple signaling cascades that regulate various cell functions. Secondly, Wnt5a can bind to Ror receptors to mediate noncanonical Wnt signaling and a significant ligand for Ror2 in vertebrates. Consistent with the multiple functions of Wnt5A/Ror2 signaling, Wnt5A knockout mice exhibited various phenotypic defects, including an inability to extend the anterior and posterior axes of the embryo. Numerous essential roles of Wnt5a/Ror2 in development have been demonstrated. Therefore, Ror signaling pathway become a necessary target for diagnosing and treating human diseases. The Wnt5a- Ror2 signaling pathway as a critical factor has attracted extensive attention.

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Section: Role Of Wnt In the Cardiovascular Systemmentioning

confidence: 99%

Roles of Wnt Signaling Pathway and ROR2 Receptor in Embryonic Development: An Update Review Article

Guo

Xing

2022

Genet Epigenet

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“…47 There is ample biological and genetic evidence to suggest that postnatal angiogenesis and de novo vasculogenesis are regularly observed in the human body at sites of injury even in the absence of preexisting vascular structures in that particular area, allegedly due to the activation of local or recruited (blood derived) progenitor cells that would have remained quiescent under normal physiologic conditions. 81,[83][84][85][86][87][88] It has been demonstrated recently that the so-called diffuse and circumscribed choroidal hemangiomas show mutations in GNAQ (R183Q) and GNAQ (Q209), respectively. 89,90 This is perhaps of no relevance to the current topic at hand, but the latter lesion (circumscribed choroidal hemangioma) is to some extent remotely evocative of a CVM.…”

Section: Infantile Hemangiomamentioning

confidence: 99%

Section: Etiology and Pathogenesismentioning

confidence: 99%

Orbital Vascular Anomalies: A Nomenclatorial, Etiological, and Nosologic Conundrum

Tawfik

Dutton

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: Vascular anomalies are a heterogeneous group of disorders that frequently present in the periorbital region. They encompass 2 broad entities: vascular tumors, which possess a proliferative endothelium, and vascular malformations, which are basically localized defects of vascular morphogenesis. The primary goal of this review was to address inaccurate or controversial terminology in the oculoplastic literature concerning orbital and periorbital vascular anomalies and to categorize these lesions in an abridged and simplified hierarchical list that adheres as much as possible to the most recent (2018) iteration for the classification of vascular lesions proposed by the International Society for the Study of Vascular Anomalies (ISSVA). The secondary goal of this review was to review and update information regarding the genetic underpinnings of vascular anomalies and the downstream signaling pathways that are subsequently affected as a result of these genetic errors. Methods: A literature review was conducted in PubMed, MEDLINE, PubMed Central, National Center for Biotechnology Information Bookshelf, and Embase for several related keywords including “vascular anomalies, vascular malformations, vascular tumors, and cavernous venous malformation,” both with and without adding the keywords “eyelid,” “orbital,” and “periorbital.” In addition, a detailed search was conducted for controversial or obsolete keywords like “cavernous hemangioma,” “lymphangioma,” and “varices,” again in their systemic and orbital/periorbital context. Results: Crucial issues in the 2018 ISSVA classification regarding the proper categorization of orbital vascular anomalies, particularly venous lesions, were critically evaluated and revised, and a regional, simplified, and abridged modification of the ISSVA 2018 classification was proposed. Conclusions: Interdisciplinary and intradisciplinary dialogue concerning orbital vascular anomalies is seriously compromised due to the lack of a unanimous agreement on terminology and the absence of a unified classification concept system. The authors recommend that oculoplastic surgeons adopt ISSVA terminology whenever technically possible and scientifically sound. However, they also propose modifying the ISSVA 2018 classification specifically to adapt to the peculiarities of vascular anomalies in the periorbital region. At present, the simplified classification proposed here is a preliminary first step towards managing patients with orbital vascular anomalies with greater diagnostic and therapeutic precision, until such time in the future when the entire genetic makeup of orbital vascular anomalies is more completely elucidated. Optimistically, this could pave the way for a more robust classification and the ultimate therapeutic cure.

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“…17,18 Therefore, the best solution is to generate vessels de novo by stimulating natural processes that occur during angiogenesis. 18 Surgical prefabrication that involves placing a fully functional vessel into a scaffold to vascularize it via overgrowing and sprouting seems to be one of the most promising methods for the stimulation of angiogenesis. [19][20][21][22][23][24][25][26][27] Another strategy involves the use of the proangiogenic properties of adipose-derived stem cells (ASCs), which have been proven to effectively stimulate angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Effect of adipose-derived stem cells seeding and surgical prefabrication on composite scaffold vascularization

Debski,

Siennicka,

Idaszek

et al. 2023

J Biomater Appl

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The study aimed to evaluate an angiogenic effect of adipose-derived stem cells (ASCs) seeding and surgical prefabrication (placing a vascular pedicle inside the scaffold) on developed composite scaffolds made of poly-ε-caprolactone (PCL), β-tricalcium phosphate (β-TCP), and poly (lactic-co-glycolic acid) (PLGA) (PCL+β-TCP+PLGA). Moreover, we aimed to compare our data with previously tested PCL scaffolds to assess whether the new material has better angiogenic properties. The study included 18 inbred male WAG rats. There were three scaffold groups (six animals each): with non-seeded PCL+β-TCP+PLGA scaffolds, with PCL+β-TCP+PLGA scaffolds seeded with ASCs and with PCL+β-TCP+PLGA scaffolds seeded with ASCs and osteogenic-induced. Each rat was implanted with two scaffolds in the inguinal region (one prefabricated and one non-prefabricated). After 2 months from implantation, the scaffolds were explanted, and vessel density was determined by histopathological examination. Prefabricated ASC-seeded PCL+β-TCP+PLGA scaffolds promoted greater vessel formation than non-seeded scaffolds (19.73 ± 5.46 vs 12.54 ± 0.81; p = .006) and those seeded with osteogenic-induced ASCs (19.73 ± 5.46 vs 11.87±2.21; p = .004). The developed composite scaffold promotes vessel formation more effectively than the previously described PCL scaffold.

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De novo Vessel Formation Through Cross-Talk of Blood-Derived Cells and Mesenchymal Stromal Cells in the Absence of Pre-existing Vascular Structures

Cited by 8 publications

References 78 publications

Roles of Wnt Signaling Pathway and ROR2 Receptor in Embryonic Development: An Update Review Article

Roles of Wnt Signaling Pathway and ROR2 Receptor in Embryonic Development: An Update Review Article

Orbital Vascular Anomalies: A Nomenclatorial, Etiological, and Nosologic Conundrum

Effect of adipose-derived stem cells seeding and surgical prefabrication on composite scaffold vascularization

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