“…Biological network analysis can generally be classified as either structural or dynamic [ 1 ]. Structural analysis provides insights into global properties of the network, among them decomposition of the network into functional modules (e.g., [ 2 ]), enumeration of signaling paths connecting arbitrary protein pairs (e.g., [ 3 - 5 ]), and the identification of key pathways that determine the behavior of the network (e.g., [ 2 , 6 - 10 ]). Dynamic methods, on the other hand, simulate the actual propagation of signals through a network by predicting the changes in the concentration of signaling proteins over time.…”