De Novo Posttransplantation Nonlymphoproliferative Malignancies in Liver Transplant Recipients

Boin, I.F.S.F.; Leonardi, M.I.; Stucchi, R.S.B.; Ataíde, Elaine Cristina de; Almeida, José R.; Barros, Ricardo Hoelz de Oliveira; Leonardi, Luiz Sérgio

doi:10.1016/j.transproceed.2007.07.084

Cited by 7 publications

(16 citation statements)

References 17 publications

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“…Studies reported in the literature are quite heterogeneous as, there was neither standardization among the series of patients who presented with DNT nor between the analytical methods. Other differences include the number of patients, ranging from 325 to 6846 [2], [19], [10], [11], [12], [13] and duration of observation time – from 5 to 27 years - in different periods ranging form 80s to 2006 [2], [10], [11], [14], [3], [15], that could affect the results.…”

Section: Discussionmentioning

confidence: 99%

“…In immunocompetent subjects, cervical cancer has been linked to Human Papilloma Virus infections, and Kaposi's sarcoma with Human Herpes Virus 8. Infection with Epstein Barr Virus is the main risk factor for developing lymphoproliferative disorders [12], [13], [18], nasopharyngeal cancer and some types of leiomyosarcoma. HCV has a controversial role [12].…”

Section: Discussionmentioning

confidence: 99%

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Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

et al. 2013

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BackgroundDe novo tumors (DNT) after liver transplantation (LT) represent a growing concern.Patients and MethodsWe analyzed the incidence of DNT, type, time of onset, risk factors and mortality (as of 2010) in 494 adult patients transplanted in the last 26 years (1983–2009).ResultsDNT occurred in 41 (8.3%) of the patients. The Standardized Incidence Ratio (SIR) compared with the Italian population was 1.8. There was a higher incidence in males (SIR 2.0), an expected extremely high rate of Kaposi’s sarcoma (SIR 127.95) and unexpected higher rates of tumors of the bladder in males (SIR 3.3). The incidence of DNT was higher within the first two years of LT (SIR 2.7) for Kaposi’s sarcoma (SIR 393.3) and after 10 years (SIR 1.7) for bladder tumors (SIR 10.6). Multivariate analysis identified alcoholic cirrhosis (HR = 3.0, 95% CI = 1.2–7.8) and sclerosing cholangitis (HR = 3.5, 95% CI = 1.1–11.3) in the recipient as main risk factors for the occurrence of DNT.ConclusionsSurveillance protocols for DNT must be specifically oriented to patients transplanted for alcoholic cirrhosis and sclerosing cholangitis. They should focus on early detection of Kaposi’s sarcomas, and more remarkably, on late development bladder tumors in men after LT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

et al. 2013

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“…When the exclusion criteria were applied, the final 29 studies were included for review ( Figure 1) (2,6,16,36,37,40) were of high, 15 of medium (3,35,(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)) and 8 of low quality according to the DQS (38,39,(54)(55)(56)(57)(58)(59). A pretransplantation screening protocol for LTx evaluation was mentioned in 2 studies (16,37 (3,6,37,40,45,52,53). Weighted age-matched control IR for the overall IR pooled analysis: In total, for 13 studies an age at the end of follow-up was extracted (2,6,16,35,37,40,(44)(45)(46)…”

Section: Study Selectionmentioning

confidence: 99%

“…After pooling the 10 studies (Figure 4) (2,6,16,37,40,45,49,52,53) (48,65,66 (6,37). One of these two studies reported a mean age of LTx of 56 years (37).…”

Section: Risk Of Crc In Post-ltx Patients: a Meta-analysis Of Follow-mentioning

confidence: 99%

Risk of Colorectal Carcinoma in Post-Liver Transplant Patients: A Systematic Review and Meta-analysis

Nicolaas

Jonge²,

Steyerberg

et al. 2010

American Journal of Transplantation

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Liver transplant patients (LTx) have an increased risk for developing de novo malignancies, but for colorectal cancer (CRC) this risk is less clear. We aimed to determine whether the CRC risk post-LTx was increased. A systematic search was performed in MEDLINE and Cochrane databases to identify studies published between 1986 and 2008 reporting on the risk of CRC postLTx. The outcomes were (1) CRC incidence rate (IR per 100 000 person-years (PY)) compared to a weighted age-matched control population using SEER and (2) relative risk (RR) for CRC compared to the general population. If no RR data were available, the RR was estimated using SEER. Twenty-nine studies were included. The overall post-LTx IR was 119 (95% CI 88-161) per 100 000 PY. The overall RR was 2.6 (95% CI 1.7-4.1). The non-primary sclerosing cholangitis (PSC) IR was 129 per 100 000 PY (95% CI 81-207). Compared to SEER (71 per 100 000 PY), the non-PSC RR was 1.8 (95% CI 1.1-2.9). In conclusion, the overall transplants and the subgroup non-PSC transplants have an increased CRC risk compared to the general population. However, in contrast to PSC, non-PSC transplants do not need an intensified screening strategy compared to the general population until a prospective study further defines recommendations.

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“…An analysis of data from the Australia and New Zealand Dialysis and Transplant Registry showed that the risk of gastric cancer was only slightly increased in transplant patients [31]; the standardized incidence ratio of [32]. Other studies, in which the incidences of malignancies after renal [33,34], liver [35][36][37], and lung [38] transplantation were described, showed few if any cases of gastric cancer. All of these reports indicate that the risk of gastric cancer does not increase after solid-organ transplantation.…”

Section: Gastric Mucosa-associated Lymphoid Tissue Lymphoma After Solmentioning

confidence: 99%

Helicobacter pylori in solid-organ transplant recipient

Ueda

Chiba²

2008

Current Opinion in Organ Transplantation

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The best management for H. pylori infection in solid-organ transplant recipients has not been established. The association with peptic ulcer disease and MALT lymphoma indicates that H. pylori-positive recipients should be treated for the eradication of H. pylori to avoid upper gastrointestinal diseases after transplantation. However, the efficacy and efficiency of H. pylori eradication therapy before transplantation should be evaluated in future studies.

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De Novo Posttransplantation Nonlymphoproliferative Malignancies in Liver Transplant Recipients

Cited by 7 publications

References 17 publications

Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

Early and Late De Novo Tumors after Liver Transplantation in Adults: The Late Onset of Bladder Tumors in Men

Risk of Colorectal Carcinoma in Post-Liver Transplant Patients: A Systematic Review and Meta-analysis

Helicobacter pylori in solid-organ transplant recipient

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