De Novo Osteogenic Sarcoma in Patients Older Than Forty

Abstract

Therapeutic study, Level III-1 (retrospective cohort study). See the Guidelines for Authors for a complete description of levels of evidence.

Osteosarcoma in the elderly over 60 years: A multicenter study by the Japanese musculoskeletal oncology group

“…These data suggest the similarities in the occurrence of osteosarcoma in the elderly between western countries and Japan. In agreement with previous published data on osteosarcoma in adults [6,11,12,[15][16][17][18], in this study there was a prominent tendency toward unusual location, especially in axial bone. Thirty-two (33.7%) cases had involvement in the pelvis, scapula, spine, or sternum, which was consistent with the rate in the previous reports of Huvos [6] (25.6%), Manoso et al [18] (19%), Carsi and Rock [11] (38.2%), and Okada et al [15] (35.9%).…”

“…In agreement with previous published data on osteosarcoma in adults [6,11,12,[15][16][17][18], in this study there was a prominent tendency toward unusual location, especially in axial bone. Thirty-two (33.7%) cases had involvement in the pelvis, scapula, spine, or sternum, which was consistent with the rate in the previous reports of Huvos [6] (25.6%), Manoso et al [18] (19%), Carsi and Rock [11] (38.2%), and Okada et al [15] (35.9%). Although secondary osteosarcoma such as Paget's sarcoma and radiation-induced sarcoma often occurs in the pelvis [4,7,19], contributing to a higher tumor incidence in axial bone, it may be that the primary osteosarcoma in those over 60 years is also more likely to involve the axial skeleton.…”

“…Although secondary osteosarcoma such as Paget's sarcoma and radiation-induced sarcoma often occurs in the pelvis [4,7,19], contributing to a higher tumor incidence in axial bone, it may be that the primary osteosarcoma in those over 60 years is also more likely to involve the axial skeleton. Studies focused on primary osteosarcoma in patients over 40 years old showed involvement of the axial skeleton in 19% [18] and 38.2% [11] of cases. Current study included so far largest series of 83 cases of primary osteosarcoma in patients aged over 60 years, of which 26 (31%) showed axial skeleton involvement.…”

A Comparison of Intramedullary and Juxtacortical Low-grade Osteogenic Sarcoma

“…This is superior to the 5-year survival for both adult patients (58%) [6] and pediatric patients (65%-75%) [7] with localized high grade disease. Furthermore, both local and distant recurrence is a late phenomenon in the dedifferentiated group on the order of several years whereas conventional high-grade tumors usually experience recurrence in the first few years.…”

Chondroblastic osteosarcoma secondary to fibrosarcoma: A case report and literature review

“…In addition, The present study the response to chemotherapy is the only proven independent factor for the prediction of survival (17). Therefore, after the surgery in the present case, individual chemotherapy and multimodality therapy was performed, as this has been shown to increase the survival rate when compared with surgery alone (18). It is noteworthy that the best time for resuming chemotherapy is within 21 days of definitive surgery.…”