De Novo Movement Disorders and <scp>COVID</scp>‐19: Exploring the Interface

Ghosh, Ritwik; Biswas, Uttam; Roy, Dipayan; Pandit, Alak; Lahiri, Durjoy; Ray, Biman Kanti; Benito‐León, Julián

doi:10.1002/mdc3.13224

Cited by 33 publications

(19 citation statements)

References 91 publications

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“…The development of transient or permanent movement disorders after viral infection is a well-established finding [ 6 , 8 ] that has also been reported after SARS-CoV-2 infection [ 2 , 3 , 5 , 6 ]. Pre-infection neurological status represents a major issue in understanding whether a direct link exists between infection and neurological changes [ 3 ].…”

mentioning

confidence: 99%

Worsening of Essential Tremor After SARS-CoV-2 Infection

et al. 2022

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confidence: 99%

Worsening of Essential Tremor After SARS-CoV-2 Infection

et al. 2022

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“…Long-term cohort studies of WNV encephalitis report unresolving cognitive and mood disorders [ 99 , 112 , 113 ]. Emerging data from COVID-19 studies show that neurological infections can induce parkinsonism and worsen Parkinson’s disease [ 114 – 118 ]. It is clear neurological infections can have severe and permanent impacts even if patients “recover” from the acute infection.…”

Section: Discussionmentioning

confidence: 99%

Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection

2022

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Dengue virus (DENV) is a flavivirus that is a significant cause of human disease costing billions of dollars per year in medical and mosquito control costs. It is estimated that up to 20% of DENV infections affect the brain. Incidence of DENV infections is increasing, which suggests more people are at risk of developing neurological complications. The most common neurological manifestations of DENV are encephalitis and encephalopathy, and movement disorders such as parkinsonism have been observed. Parkinsonism describes syndromes similar to Parkinson’s Disease where tremors, stiffness, and slow movements are observed. Parkinsonism caused by viral infection is characterized by patients exhibiting at least two of the following symptoms: tremor, bradykinesia, rigidity, and postural instability. To investigate DENV-associated parkinsonism, case studies and reports of DENV-associated parkinsonism were obtained from peer-reviewed manuscripts and gray literature. Seven reports of clinically diagnosed DENV-associated parkinsonism and 15 cases of DENV encephalitis, where the patient met the case criteria for a diagnosis of viral parkinsonism were found. Clinically diagnosed DENV-associated parkinsonism patients were more likely to be male and exhibit expressionless face, speech problems, and lymphocytosis. Suspected patients were more likely to exhibit tremor, have thrombocytopenia and low hemoglobin. Viral parkinsonism can cause a permanent reduction in neurons with consequential cognitive and behavior changes, or it can leave a latent imprint in the brain that can cause neurological dysfunction decades after recovery. DENV-associated parkinsonism is underdiagnosed and better adherence to the case definition of viral parkinsonism is needed for proper management of potential sequalae especially if the patient has an ongoing or potential to develop a neurodegenerative disease.

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“…There is mounting evidence on the neurological sequela of COVID-19 infections including new development of movement disorders. Although one may consider post-infectious or infectious phenomena of COVID-19, a recent review of de novo movement disorders related to COVID-19 infections did not report any cases of new tics or tic-like behavior ( 105 ).…”

Section: Methodsmentioning

confidence: 99%

The Rise of Functional Tic-Like Behaviors: What Do the COVID-19 Pandemic and Social Media Have to Do With It? A Narrative Review

Martindale

Mink

2022

Front. Pediatr.

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BackgroundThere has been a rise in explosive onset of tic-like behaviors during the COVID-19 pandemic. Historically, this is an uncommon phenomenology of functional movement disorders across all ages. Both the psychological burden of the pandemic and social media usage have been implicated in the rise of these tic-like behaviors.MethodsThis paper provides a narrative review of the literature on chronic tic disorders, functional tics, and mass functional illness with particular focus on the key distinguishing features, role of social media, and the role of COVID-19.ResultsThe COVID-19 pandemic has profoundly affected the mental health of many individuals, including children, adolescents, and their caregivers. Implementation of lockdowns, lifestyle disruptions, school closures, and social distancing have driven a surge in social media and digital technology use. The combination of predisposing factors, the psychological burden of the COVID-19 pandemic, and social media are implicated in the rise and spread of tic-like behaviors; which may represent a modern-day form of mass functional illness. While many of the features overlap with functional tics, there are emerging distinctive features that are important to recognize. A more encompassing term, Functional Tic-Like Behaviors, is used to better reflect multiple contributing factors.ConclusionKnowledge of these differences is essential to mitigate downstream health effects and poor outcomes.

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De Novo Movement Disorders and COVID‐19: Exploring the Interface

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 33 publications

References 91 publications

Worsening of Essential Tremor After SARS-CoV-2 Infection

Worsening of Essential Tremor After SARS-CoV-2 Infection

Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection

The Rise of Functional Tic-Like Behaviors: What Do the COVID-19 Pandemic and Social Media Have to Do With It? A Narrative Review

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