De Novo Malignancy After Solid Organ Transplantation in Children

Debray, D.; Baudouin, Véronique; Lacaille, Florence; Charbit, Marina; Rivet, Christine; Harambat, Jérôme; Iserin, Franck; Filippo, Sylvie Di; Guyot, C.

doi:10.1016/j.transproceed.2008.12.020

Cited by 46 publications

(39 citation statements)

References 4 publications

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“…Unfortunately, no series has so far examined the recurrence of a preexisting YST after LT. The recurrence rate was additionally low when taking into account the frequency of de novo malignancy after LT (3%‐26%) . However, the comparison is difficult in children due to the limited reports of LT for patients with preexisting extrahepatic malignancy.…”

Section: Discussionmentioning

confidence: 99%

Living donor liver transplantation in a pediatric patient with preexisting yolk sac tumor

Wakiya

Toyoki

Ishido

et al. 2016

Pediatric Transplantation

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There is ongoing discussion regarding the indications and timing of LT for patients with a preexisting extrahepatic malignancy. We herein report a pediatric case that underwent LDLT after therapy for YST. The patient, a 13-year-old female with biliary atresia, had undergone portoenterostomy at 2 months of age. She developed a left ovarian tumor with a high serum alpha-fetoprotein concentration at 10 years of age. She underwent left oophorectomy and was diagnosed with ovarian YST (Stage I). After surgery, hepatopulmonary syndrome progressed gradually. She was examined carefully and exhibited no findings to suggest the recurrence of YST. We decided to perform LDLT at 3 years and 6 months of age after the surgery for YST. The patient is currently alive and doing well without recurrence of YST at approximately 2 years after transplantation. There is no significant difference between the recurrence rate of preexisting extrahepatic malignancy and the incidence of de novo malignancy if specific cases are selected. The indications and period from surgery for preexisting extrahepatic malignancy to LT should thus be determined according to the type and stage of cancer.

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Section: Discussionmentioning

confidence: 99%

Living donor liver transplantation in a pediatric patient with preexisting yolk sac tumor

Wakiya

Toyoki

Ishido

et al. 2016

Pediatric Transplantation

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“…In a normal situation the recipient lymphocytes tend to repopulate the graft, while the donor cells migrate into the in cases of latent EBV infection. They also show diffuse nuclear staining with the EBER-1 probe, which highlights the monotonous population of transformed cells (Debray et al 2009 ;Nalesnik et al 2000 ;Finn et al 1998 ). Monomorphous PTLD is the second major group of EBV-related neoplasia that is seen posttransplant.…”

Section: Graft-versus-host Disease (Gvhd)mentioning

confidence: 99%

Pathology of Pediatric Gastrointestinal and Liver Disease

2014

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“…The most common malignancy to occur after intestine transplantation has been PTLD, occurring in 13% of recipients (53,54). Seventy-one percent of PTLD episodes occur in the first year and 95% are related to Epstein-Barr virus infection, which is especially common in children.…”

Section: De Novo Malignancymentioning

confidence: 99%

The Current State of Intestine Transplantation: Indications, Techniques, Outcomes and Challenges

Sudan

2014

American Journal of Transplantation

111

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Intestine transplantation is the least common form of organ transplantation in the United States and often deemed one of the most difficult. Patient and graft survival have historically trailed well behind other organ transplants. Over the past 5-10 years registry reports and single center series have demonstrated improvements to patient survival after intestinal transplantation that now match patient survival for those without life-threatening complications on parenteral nutrition. For various reasons including improvements in medical care of patients with intestinal failure and difficulty accessing transplant care, the actual number of intestine transplants has declined by 25% over the past 6 years. In light of the small numbers of intestine transplants, many physicians and the lay public are often unaware that this is a therapeutic option. The aim of this review is to describe the current indications, outcomes and advances in the field of intestine transplantation and to explore concerns over future access to this important and life-saving therapy.

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De Novo Malignancy After Solid Organ Transplantation in Children

Cited by 46 publications

References 4 publications

Living donor liver transplantation in a pediatric patient with preexisting yolk sac tumor

Living donor liver transplantation in a pediatric patient with preexisting yolk sac tumor

Pathology of Pediatric Gastrointestinal and Liver Disease

The Current State of Intestine Transplantation: Indications, Techniques, Outcomes and Challenges

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