De novo gliosarcoma occurring in the posterior fossa of a 11-year-old girl

Abstract

Figure 2. Close-up of juxtaposed glial (g) and mesenchymal (m) components. Note rich reticulin response limited to mesenchymal component. Immunohistochemistry shows GFAP confined to glial zones in contrast vimentin positivity is noted in both components. High MIB-1 labeling was evident in both components as well as p53 expression.

Primary Gliosarcoma of the Cerebellum in a Young Pregnant Woman: Management Challenges and Immunohistochemical Features

“…The first case had been described in 1990 on a 62-year-old patient, presenting with ataxia and adiadokinesia due to a cerebellar lesion which was initially mistaken for a malignant fibrous histiocytoma [14]. Following this initial report, between 1993 and 2016, a total of seven additional cases have been described, one of which in a pediatric patient [13]. Interestingly, those lesions have many commonalities: from a clinical perspective, they can either manifest with cerebellar symptoms or more abruptly with signs of raised intracranial pressure; from a pathological perspective, they tend to be locally aggressive, often with dural infiltration, and usually show intralesional necrosis associated with varying degrees of hemorrhage.…”

Gliosarcoma of Cerebello-Pontine Angle: A Case Report and Review of the Literature

“…Ng and Poon [ 10 ] first reported on a case of radiation induced cerebellar GS in 1990, several case reports about cerebellar GS have been published ( Table 1 ). Only very few cases have been reported about primary GS in infratentorial region [ 9 10 11 12 13 14 ].…”

Primary Cerebellar Gliosarcoma with Extracranial Metastases: An Orphan Differential Diagnosis

“…While many cases of supratentorial gliosarcomas have been reported in the literature, especially in the temporal lobes, [5] there are only a few reports of infratentorial gliosarcoma. [3,[7][8][9]15] To the best of our knowledge, this is the 6 th published case report of a primary infratentorial gliosarcoma. This is the first case associated with an extracranial metastasis to the lungs.…”

“…His clinical status remained stable with no clinical or radiological evidence of recurrence through the most recent followup examination, one year later. [Discussion:Gliosarcomas, WHO IV, are uncommon malignant primary tumors of the brain that account for 1.8 to 8% of all glioblastomas[3]. They affect the adult are considered as a monoclonal neoplasm resulting from aberrant mesenchymal differentiation of glial cells and, hence, considered to be a variant of glioblastoma [3].…”