De novo generation of SARS-CoV-2 antibody CDRH3 with a pre-trained generative large language model
Haohuai He,
Bing He,
Lei Guan
et al.
Abstract:Artificial Intelligence (AI) techniques have made great advances in assisting antibody design. However, antibody design still heavily relies on isolating antigen-specific antibodies from serum, which is a resource-intensive and time-consuming process. To address this issue, we propose a Pre-trained Antibody generative large Language Model (PALM-H3) for the de novo generation of artificial antibodies heavy chain complementarity-determining region 3 (CDRH3) with desired antigen-binding specificity, reducing the … Show more
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