De novo discovery of neuropeptides in the genomes of parasitic flatworms using a novel comparative approach

Koziol, Uriel; Koziol, Miguel; Preza, Matías; Costábile, Alicia; Brehm, Klaus; Castillo, Estela

doi:10.1016/j.ijpara.2016.05.007

Cited by 46 publications

(58 citation statements)

References 70 publications

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“…Our phylogeny (Figure 2A) suggests that fwRhods are more similar to peptide than amine receptors. If their heterologous expression can be achieved, one approach to characterisation would be to screen them with the growing canon of peptide ligands from flatworms [36–38], as well as from other genera, in a receptor activation assay. Subsequent localisation of their spatial expression patterns would provide additional data that would inform function.…”

Section: Resultsmentioning

confidence: 99%

Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes

McVeigh

McCammick

McCusker

et al. 2017

Preprint

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Section: Resultsmentioning

confidence: 99%

Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes

McVeigh

McCammick

McCusker

et al. 2017

Preprint

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“…They might hold important, yet hidden, functional aspects that would allow a complete understanding of the interaction between infective plerocercoids and their fish host (Koziol et al . ).…”

Section: Detecting Distinct Developmental Stages Within the Same Hostmentioning

confidence: 97%

“…These sequences were thus labelled as infective-specific and coexpressed with genes involved in environmental sensing and interaction (Table S1, Supporting information). They might hold important, yet hidden, functional aspects that would allow a complete understanding of the interaction between infective plerocercoids and their fish host (Koziol et al 2016).…”

Section: Detecting Distinct Developmental Stages Within the Same Hostmentioning

confidence: 99%

Major host transitions are modulated through transcriptome‐wide reprogramming events in Schistocephalus solidus, a threespine stickleback parasite

et al. 2017

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Parasites with complex life cycles have developed numerous phenotypic strategies, closely associated with developmental events, to enable the exploitation of different ecological niches and facilitate transmission between hosts. How these environmental shifts are regulated from a metabolic and physiological standpoint, however, still remain to be fully elucidated. We examined the transcriptomic response of Schistocephalus solidus, a trophically transmitted parasite with a complex life cycle, over the course of its development in an intermediate host, the threespine stickleback, and the final avian host. Results from our differential gene expression analysis show major reprogramming events among developmental stages. The final host stage is characterized by a strong activation of reproductive pathways and redox homoeostasis. The attainment of infectivity in the fish intermediate host—which precedes sexual maturation in the final host and is associated with host behaviour changes—is marked by transcription of genes involved in neural pathways and sensory perception. Our results suggest that un‐annotated and S. solidus‐specific genes could play a determinant role in host–parasite molecular interactions required to complete the parasite's life cycle. Our results permit future comparative analyses to help disentangle species‐specific patterns of infection from conserved mechanisms, ultimately leading to a better understanding of the molecular control and evolution of complex life cycles.

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“…important, yet hidden, functional aspects that would allow a complete understanding of the 455 interaction between infective plerocercoids and their fish host (Koziol et al 2016). (Table S1).…”

Section: Regulation Of Redox Pathways Through Novel Species-specific mentioning

confidence: 99%

Major host transitions are modulated through transcriptome-wide reprograming events inSchistocephalus solidus, a threespine stickleback parasite

Hébert

Grambauer

Barber

et al. 2016

Preprint

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Parasites with complex life cycles have developed numerous phenotypic strategies, closely associated with developmental events, to enable the exploitation of different ecological niches and facilitate transmission between hosts. How these environmental shifts are regulated from a metabolic and physiological standpoint, however, still remain to be fully elucidated. We examined the transcriptomic response of Schistocephalus solidus, a trophically-transmitted parasite with a complex life cycle, over the course of its development in an intermediate host, the threespine stickleback, and the final avian host. Results from our differential gene expression analysis show major reprogramming events among developmental stages. The final host stage is characterized by a strong activation of reproductive pathways and redox homeostasis. The attainment of infectivity in the fish intermediate host – which precedes sexual maturation in the final host and is associated with host behaviour changes – is marked by transcription of genes involved in neural pathways and sensory perception. Our results suggest that un-annotated and S. solidus-specific genes could play a determinant role in host-parasite molecular interactions required to complete the parasite’s life cycle. Our results permit future comparative analyses to help disentangle species-specific patterns of infection from conserved mechanisms, ultimately leading to a better understanding of the molecular control and evolution of complex life cycles.

show abstract

De novo discovery of neuropeptides in the genomes of parasitic flatworms using a novel comparative approach

Cited by 46 publications

References 70 publications

Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes

Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes

Major host transitions are modulated through transcriptome‐wide reprogramming events in Schistocephalus solidus, a threespine stickleback parasite

Major host transitions are modulated through transcriptome-wide reprograming events inSchistocephalus solidus, a threespine stickleback parasite

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