De novo design of pimarane diterpenoid compounds as potential alternatives to sarecycline for acne vulgaris treatment
Adeola Tawakalitu Kola-Mustapha
Abstract:Acne vulgaris is a prevalent skin disorder that affects both adolescents and adults and has a major psychological impact. Antibiotic resistance is one issue that current therapies, including antibiotics, must address. A viable approach is to target Cutibacterium acnes, a crucial bacterium in the development of acne. An antibiotic of the tetracycline class called sarecycline shows efficacy despite resistance and adverse effect issues. The purpose of this study is to develop, assess, and compare the efficacy of … Show more
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