De novo and relapsing glomerulonephritis after <scp>COVID</scp>‐19 vaccination: how much do we know?

Chan, Anthony T P; Tang, Sydney C.W.

doi:10.1111/nep.14013

Cited by 12 publications

(9 citation statements)

References 14 publications

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“…4 Among such associations, many new-onset and recurrent cases of glomerulonephritis have been reported. [5][6][7][8][9][10][11] Specific types of glomerulonephritis most often reported after SARS-CoV-2 vaccination include IgA nephropathy (IgAN), minimal change disease (MCD), membranous nephropathy (MN) and pauci-immune necrotizing glomerulonephritis (PINGN), the renal manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).…”

Section: Introductionmentioning

confidence: 99%

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Incidence of new onset glomerulonephritis after SARS-CoV-2 mRNA vaccination is not increased

Diebold

Locher

Boide

et al. 2022

Kidney International

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Section: Introductionmentioning

confidence: 99%

“…While mechanistically plausible, 5,7,11 a causal link between SARS-CoV-2 vaccination and glomerulonephritis has not been formally established. Published case series lack control groups, and estimates of incidence of these glomerulonephritides before and during the vaccination campaign have not been published yet.…”

Section: Introductionmentioning

confidence: 99%

Incidence of new onset glomerulonephritis after SARS-CoV-2 mRNA vaccination is not increased

Diebold

Locher

Boide

et al. 2022

Kidney International

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“…Although this finding could be incidental, a heightened immune response after vaccination in patients with potential autoimmune diathesis may play a role. Autoantibodies are being evaluated as potential mechanisms for various AEs following COVID-19 vaccination, including myocarditis, thrombosis with thrombocytopenia syndrome, and glomerulonephritis [3,22,23].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review

Park

Kim

Park

et al. 2022

Korean J Intern Med

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Background/Aims: Pulmonary toxicities of coronavirus disease 2019 (COVID-19) vaccination are exceedingly rare. However, there are a few reported cases after mRNA vaccination, especially from Asian countries. The purpose of this study was to report the clinical characteristics of patients with COVID-19 vaccine-related pneumonitis (CV-P) and to review cases reported in the literature. Methods: We performed a prospective, observational case series analysis. Results: Eleven patients with a median age of 80 years were enrolled. Ten patients developed CV-P after BNT162b2-mRNA vaccination and one after ChAdOx1 nCoV-19 vaccination. We identified various patterns of CV-P, including transient infiltration, life-threatening acute respiratory distress syndrome, and aggravation of underlying interstitial lung disease. Most patients showed favorable outcomes with good responses to corticosteroid therapy. Conclusions: Identifying the mechanism of CV-P requires further investigation; however, radiological and laboratory findings in our case series support inflammatory dysregulation in the lung parenchyma after vaccination. Clinicians should consider CV-P in patients with atypical lung infiltration, no specific etiologies, and recent COVID-19 vaccination.

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“…It is well established that the immune response generated by the most diverse vaccines, such as vaccines against meningococcus C and B virus, influenza, and diphtheriatetanus-pertussis (DTP), is a potential trigger for developing or reactivating nephrotic syndrome (36)(37)(38)(39)(40). However, in the most recently published studies related to post-vaccination conditions against COVID-19, in addition to nephrotic conditions, other forms of renal involvement have been reported, such as acute tubular necrosis and thrombotic microangiopathies (Table 1).…”

Section: Morphological Findings In Renal Involvement Post Covid-19 Va...mentioning

confidence: 99%

Kidney injury associated with COVID-19 infection and vaccine: A narrative review

et al. 2022

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The respiratory tract is the main infection site for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in many admissions to intensive care centers in several countries. However, in addition to lung involvement, kidney injury caused by the novel coronavirus has proven to be a significant factor related to high morbidity and mortality, alarming experts worldwide. The number of deaths has drastically reduced with the advent of large-scale immunization, highlighting the importance of vaccination as the best way to combat the pandemic. Despite the undeniable efficacy of the vaccine, the renal side effects associated with its use deserve to be highlighted, especially the emergence or reactivation of glomerulopathies mentioned in some case reports. This study aimed to identify the main renal morphological findings correlated with COVID-19 infection and its vaccination, seeking to understand the pathophysiological mechanisms, main clinical features, and outcomes.

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De novo and relapsing glomerulonephritis after COVID‐19 vaccination: how much do we know?

Cited by 12 publications

References 14 publications

Incidence of new onset glomerulonephritis after SARS-CoV-2 mRNA vaccination is not increased

Incidence of new onset glomerulonephritis after SARS-CoV-2 mRNA vaccination is not increased

Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review

Kidney injury associated with COVID-19 infection and vaccine: A narrative review

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