De Marco Formula effectiveness as an adjunctive therapy to prevent infected ischemic diabetic foot amputation and reduce plasma fibrinogen

Mesa, Milagros García; Duarte, Héctor Álvarez; Carretero, José; Fors, Martha; Vilas, Miriam Mahía

doi:10.1016/j.jtv.2010.12.003

Cited by 4 publications

(4 citation statements)

References 20 publications

(9 reference statements)

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“…It is hard to draw firm conclusions from the study, because interpretation of the results was severely limited by missing details. The same group published another study of De Marco formula on patients with an ischemic diabetic foot ulcer, but it contained no infection‐related outcomes so did not add to the conclusions of the other report …”

Section: Resultsmentioning

confidence: 99%

Interventions in the management of infection in the foot in diabetes: a systematic review

Peters

Lipsky

Senneville

et al. 2020

Diabetes Metabolism Res

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The optimal approaches to managing diabetic foot infections remain a challenge for clinicians. Despite an exponential rise in publications investigating different treatment strategies, the various agents studied generally produce comparable results, and high‐quality data are scarce. In this systematic review, we searched the medical literature using the PubMed and Embase databases for published studies on the treatment of diabetic foot infections as of June 2018. This systematic review is an update of previous reviews, the first of which was undertaken in 2010 and the most recent in 2014, by the infection committee of the International Working Group of the Diabetic Foot. We defined the context of literature by formulating clinical questions of interest, then developing structured clinical questions (PICOs) to address these. We only included data from controlled studies of an intervention to prevent or cure a diabetic foot infection. Two independent reviewers selected articles for inclusion and then assessed their relevant outcomes and the methodological quality. Our literature search identified a total of 15 327 articles, of which we selected 48 for full‐text review; we added five more studies discovered by means other than the systematic literature search. Among these selected articles were 11 high‐quality studies published in the last 4 years and two Cochrane systematic reviews. Overall, the outcomes in patients treated with the different antibiotic regimens for both skin and soft tissue infection and osteomyelitis of the diabetic foot were broadly equivalent across studies, except that treatment with tigecycline was inferior to ertapenem (±vancomycin). Similar outcomes were also reported in studies comparing primarily surgical and predominantly antibiotic treatment strategies in selected patients with diabetic foot osteomyelitis. There is insufficient high‐quality evidence to assess the effect of various adjunctive therapies, such as negative pressure wound therapy, topical ointments or hyperbaric oxygen, on infection related outcomes of the diabetic foot. In general, the quality of more recent trial designs are better in past years, but there is still a great need for further well‐designed trials to produce higher quality evidence to underpin our recommendations.

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Section: Resultsmentioning

confidence: 99%

Interventions in the management of infection in the foot in diabetes: a systematic review

Peters

Lipsky

Senneville

et al. 2020

Diabetes Metabolism Res

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“…A DFU characteristic feature is an acute-phase reaction prolongation [5]. Acute-phase reactants C-reactive protein (CRP), white blood cell (WBC), neutrophil count, and platelet are commonly used as a predictor of amputation in the patients with DFU but have only modest accuracy in reflecting DFU disease severity [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Fibrinogen: A Marker in Predicting Diabetic Foot Ulcer Severity

Guan

Lin

et al. 2016

Journal of Diabetes Research

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Aims. To examine whether fibrinogen levels are a valuable biomarker for assessing disease severity and monitoring disease progression in patients with diabetic foot ulcer (DFU). Methods. A retrospective study was designed to examine the utility of fibrinogen in estimating disease severity in patients with DFU admitted to our hospital between January 2015 and January 2016. In total, 152 patients with DFU were enrolled in the study group, and 52 age and gender matched people with diabetes but no DFU were included as the control group. DFU severity was assessed using Wagner criteria. Results. Patients with DFU were divided into 2 subgroups based on the Wagner criteria. Mean fibrinogen values were significantly higher in patients with DFU grade ≧ 3 compared to those with DFU grades 1-2 (5.23 ± 1.37 g/L versus 3.61 ± 1.04 g/L). Using ROC statistic, a cut-off value of 5.13 g/L indicated the possible amputation with a sensitivity of 81.8% and a specificity of 78.9% (positive predictive value [PPV] 78.6%, negative predictive value [89.0%]). Fibrinogen values were found to be correlated with CRP levels, neutrophil, and WBC count. Conclusions. Fibrinogen levels might be a valuable tool for assessing the disease severity and monitoring the disease progression in patients with DFU.

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“…It is hard to draw any solid conclusions from the study because it was severely limited by missing details. Although one other study of this intramuscular preparation was published, it contained no infection‐related outcomes, and it therefore did not add to the conclusions of the other report .…”

Section: Resultsmentioning

confidence: 99%

Interventions in the management of infection in the foot in diabetes: a systematic review

Peters

Lipsky

Aragón‐Sánchez

et al. 2016

Diabetes Metabolism Res

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The expert panel on diabetic foot infection (DFI) of the International Working Group on the Diabetic Foot conducted a systematic review seeking all published reports relating to any type of treatment for infection of the foot in persons with diabetes published as of 30 June 2014. This review, conducted with both PubMed and EMBASE, was used to update an earlier one undertaken on 30 June 2010 using the same search string. Eligible publications included those that had outcome measures reported for both a treated and a control population that were managed either at the same time, or as part of a before-and-after case design. We did not include studies that contained only information related to definition or diagnosis, but not treatment, of DFI. The current search identified just seven new articles meeting our criteria that were published since the 33 identified with the previous search, making a total of 40 articles from the world literature. The identified articles included 37 randomised controlled trials (RCTs) and three cohort studies with concurrent controls, and included studies on the use of surgical procedures, topical antiseptics, negative pressure wound therapy and hyperbaric oxygen. Among the studies were 15 RCTs that compared outcomes of treatment with new antibiotic preparations compared with a conventional therapy in the management of skin and soft tissue infection. In addition, 10 RCTs and 1 cohort study compared different treatments for osteomyelitis in the diabetic foot. Results of comparisons of different antibiotic regimens generally demonstrated that newly introduced antibiotic regimens appeared to be as effective as conventional therapy (and also more cost-effective in one study), but one study failed to demonstrate non-inferiority of a new antibiotic compared with that of a standard agent. Overall, the available literature was both limited in both the number of studies and the quality of their design. Thus, our systematic review revealed little evidence upon which to make recommendations for treatment of DFIs. There is a great need for further well-designed trials that will provide robust data upon which to make decisions about the most appropriate treatment of both skin and soft tissue infection and osteomyelitis in diabetic patients.

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De Marco Formula effectiveness as an adjunctive therapy to prevent infected ischemic diabetic foot amputation and reduce plasma fibrinogen

Cited by 4 publications

References 20 publications

Interventions in the management of infection in the foot in diabetes: a systematic review

Interventions in the management of infection in the foot in diabetes: a systematic review

Fibrinogen: A Marker in Predicting Diabetic Foot Ulcer Severity

Interventions in the management of infection in the foot in diabetes: a systematic review

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