In CDMA-based wireless networks users share the same frequency bands, and can transmit simultaneously. Transmissions from one user causes interference to other users, hence a CDMA-based system is typically interference-limited. The management of mutual interference is directly related to system capacity, and quality of service delivered to the users. This paper shows that by adopting binary De Bruijn sequences as spreading codes in dense CDMA-based systems, it is possible to arrange more users within the same frequency bandwidth, and limit the impact of interference at the same time, with respect to wellknown and traditionally adopted sets of spreading codes.