DDT Exposure in Utero and Breast Cancer

Cohn, Barbara A.; Merrill, Michele A. La; Krigbaum, Nickilou Y.; Yeh, Gregory; Park, June Soo; Zimmermann, Lauren; Cirillo, Piera M.

doi:10.1210/jc.2015-1841

Cited by 237 publications

(159 citation statements)

References 49 publications

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“…In preliminary studies by our group and other groups, the environmental pollutants polychlorinated biphenyls (PCBs) have demonstrated a propensity to disturb systemic iron homeostasis through estrogenic effects, increasing breast cancer risk 40, 41, 42. A recent study by Cohn et al suggested that dichlorodiphenyltrichloroethane (DDT) exposure during pregnancy leads to increased risk of breast cancer later in life 43. BPA, one of the most ubiquitous and thoroughly studied EDCs, is also weakly estrogenic and there has been concern regarding the role BPA may play in the development of breast cancer over years 44, 45, 46.…”

Section: Introductionmentioning

confidence: 99%

Low‐Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer

2016

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Breast cancer is the fifth most common cause of cancer death in the world and the second most common fatal cancer in women. Epidemiological studies and clinical data have indicated that hormones, including estrogen, progesterone, and prolactin, play important roles in the initiation and progression of breast cancer. Bisphenol A (BPA) is one of the most commonly used and thoroughly studied endocrine disruptors. It can be released from consumer products and deposited in the environment, thus creating potential for human exposure through oral, inhaled, and dermal routes. Some recent reviews have summarized the known mechanisms of endocrine disruptions by BPA in human diseases, including obesity, reproductive disorders, and birth defects. However, large knowledge gaps still exist on the roles BPA may play in cancer initiation and development. Evidence from animal and in vitro studies has suggested an association between increased incidence of breast cancer and BPA exposure at doses below the safe reference doses that are the most environmentally relevant. Most current studies have paid little attention to the cancer‐promoting properties of BPA at low doses. In this review, recent findings on the carcinogenic effects of low‐dose BPA on breast cancer and discussed possible biologic mechanisms are summarized.

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Section: Introductionmentioning

confidence: 99%

Low‐Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer

2016

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“…The strongest relationship was seen in women who were <14 years in 1945 [odds ratio (OR) = 5.4, 95% CI 1.7-17.1]. This study, which cannot be replicated because of the unusual nature of the data set, supports the concept that the timing of exposure (i.e., early development window) may be critical to the contribution of EDCs to carcinogenesis (23). Supportive evidence comes from the Sister Study, which found that young girls up to age 18 years who were exposed to fogger truck or plane spraying of DDT were at a nonsignificant increased risk of breast cancer [hazard ratio (HR) = 1.3, 95% CI: 0.92-1.7] for premenopausal breast cancer (100).…”

Section: Pesticidesmentioning

confidence: 71%

Environmental Determinants of Breast Cancer

Hiatt

Brody

2024

Annual Review of Public Health

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In the United States, breast cancer is the most common invasive malignancy and the second most common cause of death from cancer in women. Reproductive factors, estrogen, and progesterone have major causal roles, but concerns about other potential causes in the external environment continue to drive research inquiries and stimulate calls for action at the policy level. The environment is defined as anything that is not genetic and includes social, built, and chemical toxicant aspects. This review covers the scope of known and suspected environmental factors that have been associated with breast cancer and illustrates how epidemiology, toxicology, and mechanistic studies work together to create the full picture of environmental effects on this malignancy. Newer approaches to risk-related evaluations may allow this field to move forward and more clearly delineate actionable environmental causes of this most common of cancers in women.

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“…These data are drawn from cancer registries covering a sample of the general population that is representative in sex, race, and age. 2 The increase in incidence is remarkably similar among infants (ages 0-4) and among teenagers (ages [15][16][17][18][19], whereas the rates in the middle years are lower and rising only slightly. Siegel et al 3 recently reported that the overall cancer incidence rate in the years 2001 to 2009 was rising among African American children more rapidly than among white children.…”

mentioning

confidence: 99%

“…There are important but still limited data demonstrating that exposures to chemical carcinogens and radiation during the critical developmental periods of gestation, childhood, and adolescence can lead to cancers much later in life. 8,14,15 The underlying causal web for exposures in childhood that lead to cancer later in life is undoubtedly complex, and we may never arrive at a definitive understanding of all the causes and their relative importance. But in our view, the unexplained and striking increases in childhood cancer incidence rates ( Fig 1) and the steady increases in some adult cancers with strong links to chemical exposures such as non-Hodgkin lymphoma and kidney cancer, noted earlier, justify a call to take steps now to prevent carcinogen exposures, beginning in childhood.…”

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confidence: 99%

Environmental and Economic Strategies for Primary Prevention of Cancer in Early Life

et al. 2016

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This article summarizes the evidence for environmental toxic exposures contributing to cancers in early life, focusing on the most common cancer sites in this age group. It provides examples of widespread avoidable exposures to human carcinogens through air, water, and food and then describes recent examples of successful initiatives to reduce exposure to chemicals linked to these cancer sites, through government policy, industry initiatives, and consumer activism. State government initiatives to reduce toxic chemical exposures have made important gains; the Toxics Use Reduction Act of Massachusetts is now 25 years old and has been a major success story. There are a growing number of corporate initiatives to eliminate toxics, especially carcinogens, from the products they manufacture and sell. Another important opportunity for cancer prevention is provided by online databases that list chemicals, their toxicity, and lower-toxicity alternatives; these can be used by businesses, health care institutions, consumers, and workers to reduce exposures to chemicals of concern. The article concludes by inviting pediatricians and public health professionals to include elimination of carcinogen exposures in their work to promote primary prevention of cancer in early life.

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DDT Exposure in Utero and Breast Cancer

Cited by 237 publications

References 49 publications

Low‐Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer

Low‐Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer

Environmental Determinants of Breast Cancer

Environmental and Economic Strategies for Primary Prevention of Cancer in Early Life

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