DD genotype of ACE gene I/D polymorphism is associated with Behcet disease in a Turkish population

Abstract

Behcet's disease (BD) is a chronic, multi-systemic and inflammatory disorder. The local renin-angiotensin system (RAS) in the vessel wall plays a role in the endothelial control and contributes to inflammatory processes. Angiotensin-converting enzyme (ACE) is the regulatory component of the RAS. This study was conducted in Turkish patients with BD to determine the frequency of I/D polymorphism genotypes of ACE gene. Genomic DNA obtained from 566 persons (266 patients with BD and 300 healthy controls). ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction using I and D allele-specific primers. There was statistically significant difference between the groups with respect to genotype distribution (p < 0.001). This study is the largest study in Turkish population that ACE gene I/D polymorphism investigated in BD. As a result of this study, ACE gene I/D polymorphism DD genotype could be a genetic marker in BD in Turkish study population.

Investigations of genetic polymorphisms related to Behcet\s disease in Turkish population

“…ACE genine ait insersiyon/delesyon (I/D) polimorfizmi DD ve II homozigotları ve ID heterozigotu olmak üzere üç genotip içermektedir. DD homozigot olanların yüksek, II homozigot olanların düşük, ID heterozigot olanların ise orta seviyede plazma ACE seviyeleri olduğu gösterilmiştir (74 (78).…”

Angiotensin‐converting enzyme gene insertion/deletion polymorphism and family history in severe acne vulgaris

“…The association between ACE gene I/D polymorphism and different skin disorders had been previously investigated but it was not investigated in AV. So, we tried to reveal the hypothesized link between ACE gene I/D polymorphism, and AV risk among a sample of patients.…”

“…nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) which augments reactive oxygen species (ROS) production, resulting in an oxidative stress state. 8 The association between ACE gene I/D polymorphism and different skin disorders had been previously investigated [9][10][11][12] but it was not investigated in AV. So, we tried to reveal the hypothesized link between ACE gene I/D polymorphism, and AV risk among a sample of patients.…”

Elevation of Serum Angiotensin-Converting Enzyme Level in Patients with Ocular Toxocariasis

“…Furthermore, serum ACE levels may be elevated in many diseases, including Gaucher's disease, leprosy, lymphoma, diabetes, hyperthyroidism, liver cirrhosis, and pulmonary tuberculosis [4]. Recently, several studies reported an association between ACE gene polymorphisms and rheumatologic disease, including ankylosing spondylitis and Behcet's disease [5,6].…”