DCC Expression by Neurons Regulates Synaptic Plasticity in the Adult Brain

Horn, Katherine E.; Glasgow, Stephen D.; Gobert, Delphine; Bull, Sarah-Jane; Luk, Tamarah L.; Girgis, Jacklyn; Tremblay, Marie‐Ève; McEachern, Danielle; Bouchard, Jean‐François; Haber, Michael; Hamel, Édith; Krimpenfort, Paul; Murai, Keith K.; Berns, Anton; Doucet, Guy; Chapman, C. Andrew; Ruthazer, Edward S.; Kennedy, Timothy E.

doi:10.1016/j.celrep.2012.12.005

Cited by 118 publications

(158 citation statements)

References 59 publications

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“…3) encompasses a single gene, DCC, encoding the netrin receptor. This gene shows abundant expression in dopaminergic neurons, and behavioral studies of DCC-deficient mice show altered dopaminergic system organization, culminating in impaired memory, behavior, and reward responses (46,47). Two additional regions on chromosome B3 harbor strong signatures of selection (Fig.…”

Section: Resultsmentioning

confidence: 99%

Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication

Montague

Gandolfi

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

265

269

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Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, we identified positively selected genes enriched for genes involved in lipid metabolism that underpin adaptations to a hypercarnivorous diet. We also found positive selection signals within genes underlying sensory processes, especially those affecting vision and hearing in the carnivore lineage. We observed an evolutionary tradeoff between functional olfactory and vomeronasal receptor gene repertoires in the cat and dog genomes, with an expansion of the feline chemosensory system for detecting pheromones at the expense of odorant detection. Genomic regions harboring signatures of natural selection that distinguish domestic cats from their wild congeners are enriched in neural crest-related genes associated with behavior and reward in mouse models, as predicted by the domestication syndrome hypothesis. Our description of a previously unidentified allele for the gloving pigmentation pattern found in the Birman breed supports the hypothesis that cat breeds experienced strong selection on specific mutations drawn from random bred populations. Collectively, these findings provide insight into how the process of domestication altered the ancestral wildcat genome and build a resource for future disease mapping and phylogenomic studies across all members of the Felidae.Felis catus | domestication | genome T he domestic cat (Felis silvestris catus) is a popular pet species, with as many as 600 million individuals worldwide (1). Cats and other members of Carnivora last shared a common ancestor with humans ∼92 million years ago (2, 3). The cat family Felidae includes ∼38 species that are widely distributed across the world, inhabiting diverse ecological niches that have resulted in divergent morphological and behavioral adaptations (4). The earliest archaeological evidence for human coexistence with cats dates to ∼9.5 kya in Cyprus and ∼5 kya in central China (5, 6), during periods when human populations adopted more agricultural lifestyles. Given their sustained beneficial role surrounding vermin control since the human transition to agriculture, any selective forces acting on cats may have been minimal subsequent to their domestication. Unlike many other domesticated mammals bred for food, herding, hunting, or security, most of the 30-40 cat breeds originated recently, within the past 150 y, largely due to selection for aesthetic rather than functional traits.Previous studies have assessed breed differentiation (6, 7), phylogenetic origins of the domestic cat (8), and the extent of recent introgression between domestic cats and wildcats (9, 10). However, little is known regarding the impact of the domestication process within the genomes of modern cats and how this compares with genetic changes accompanying selection identified...

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Section: Resultsmentioning

confidence: 99%

Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication

Montague

Gandolfi

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

265

269

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“…(Mironova and Giger, 2013). Following a study by Horn et al (2013), the netrin receptor DCC now joins this list.…”

Section: Funding and Disclosurementioning

confidence: 99%

Maintaining and Modifying Connections: Roles for Axon Guidance Cues in the Mature Nervous System

Thompson-Steckel

Kennedy²

2013

Neuropsychopharmacol

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“…4, J-L and N-P Slit ligands, and other axon guidance molecules are also present in the hippocampus (43). For instance, the Netrin receptor DCC (deleted in colorectal cancer) is enriched in the postsynaptic density, where it is required to facilitate long term potentiation, an electrophysiological paradigm for learning and memory (46). Therefore, it seemed plausible that Robo receptors might contribute to acute neuronal signaling events that control synaptic strength.…”

Section: Akap79 Interacts With the Robo2mentioning

confidence: 99%

A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors

Samelson

Gore

Whiting

et al. 2015

Journal of Biological Chemistry

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Background: A-kinase anchoring proteins position signaling enzymes to control neuronal phosphorylation events. Results: Biochemical and cellular approaches confirm that the AKAP79/150 signaling complex interfaces with the cytoplasmic tail of Roundabout (Robo) receptors. Conclusion: AKAP79/150-associated protein kinase C facilitates the phosphorylation of Ser-1330 on the Robo3.1 isoform. Significance: Kinase anchoring is a mechanism to control the phosphorylation of Robo3.1 within macromolecular assemblies.

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DCC Expression by Neurons Regulates Synaptic Plasticity in the Adult Brain

Cited by 118 publications

References 59 publications

Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication

Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication

Maintaining and Modifying Connections: Roles for Axon Guidance Cues in the Mature Nervous System

A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors

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