DC Polarographic and UV Spectrometric Studies of Substituted Furo[3,2-b]- and Furo[2,3-b]pyrroles

Abstract

The aim of the synthesis of substituted furo[3,2-b]- and furo[2,3-b]pyrroles was to discover biologically active compounds. On that account, their potential carcinogenicity was tested by DC polarographic assay in the presence of α-lipoic acid. Only one of the studied compounds showed a marginal carcinogenic activity, the other exhibited only a negligible carcinogenic potential under the conditions studied. Their apparent ionization constants, determined by spectrometric titration, were correlated with their structure. The results confirm that the presence of methyl, furyl and/or phenyl groups affects the ionization.