DBS therapy for the vegetative state and minimally conscious state

Yamamoto, Takamitsu; Kobayashi, Kazuhiko; Kasai, Masahiko; Oshima, Hideki; Fukaya, Chikashi; Katayama, Yoichi

doi:10.1007/3-211-27577-0_17

Cited by 68 publications

(47 citation statements)

References 8 publications

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“…La DBS est une technique hautement invasive, mais qui montre certains résultats prometteurs. À la suite d'une DBS au niveau de la formation réticulée, par exemple, 8 patients en EV/ENR chronique sur 21 ont récupéré une réponse à la commande et 4 patients en ECM sur 5 ont récupéré une communication fonctionnelle [81]. Cependant, cette étude ne comporte pas de comparateur placebo.…”

Section: Revalidation Cliniqueunclassified

Diagnostic, pronostic et traitements des troubles de la conscience

Cassol

Aubinet

Thibaut

et al. 2018

NPG Neurologie - Psychiatrie - Gériatrie

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ARTICLE IN PRESSSummary Advances in medicine and intensive care have led to an increase in the number of patients surviving a severe brain injury. Although some patients recover quickly, others remain in a state of altered consciousness. These patients can progress from a coma to a vegetative state or unresponsive wakefulness syndrome (VS/UWS) and later to a minimally conscious state (MCS). In this review, we first describe the different behavioral and neuroimaging methods used in the diagnosis of patients in an altered state of consciousness. We then describe the factors that can influence the prognosis and recovery of these patients, as well as the treatment and therapeutic management that can be proposed in order to improve their state of consciousness. Finally, we conclude this review by highlighting ethical considerations and end-of-life issues.

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Section: Revalidation Cliniqueunclassified

Diagnostic, pronostic et traitements des troubles de la conscience

Cassol

Aubinet

Thibaut

et al. 2018

NPG Neurologie - Psychiatrie - Gériatrie

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“…They received continuous stimulation for 10 years. Eight of the 21 patients emerged from a vegetative state and were able to follow verbal instructions [21][22][23]. A case study observed improvements in the level of arousal, limb movement and verbalization after DBS to the central thalamus [24].…”

Section: Deep Brain Stimulationmentioning

confidence: 99%

A Review of Neuromodulation in the Neurorehabilitation

Yin¹,

Slavin²

2015

Int J Neurorehabilitation Eng

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“…A clinical trial involving vegetative or minimally conscious patients studied DBS of the midbrain reticular formation or central thalamus in vegetative or minimally conscious patients, beginning 4-8 months following injury. 158,161 The patients were continuously stimulated and observed for 10 years, and 8 of the 21 patients emerged from a vegetative state and were able to follow verbal instructions. In a followup study, Yamamoto et al created a set of electrophysiological criteria for DBS implantation in this same cohort by analyzing electroencephalography, auditory brainstem responses, somatosensory evoked potentials, and pain-related evoked potentials.…”

Section: Dbs In the Mcsmentioning

confidence: 99%

Neurostimulation for traumatic brain injury

Shin

Dixon²,

Okonkwo³

et al. 2014

JNS

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Traumatic brain injury (TBI) remains a significant public health problem and is a leading cause of death and disability in many countries. Durable treatments for neurological function deficits following TBI have been elusive, as there are currently no FDA-approved therapeutic modalities for mitigating the consequences of TBI. Neurostimulation strategies using various forms of electrical stimulation have recently been applied to treat functional deficits in animal models and clinical stroke trials. The results from these studies suggest that neurostimulation may augment improvements in both motor and cognitive deficits after brain injury. Several studies have taken this approach in animal models of TBI, showing both behavioral enhancement and biological evidence of recovery. There have been only a few studies using deep brain stimulation (DBS) in human TBI patients, and future studies are warranted to validate the feasibility of this technique in the clinical treatment of TBI. In this review, the authors summarize insights from studies employing neurostimulation techniques in the setting of brain injury. Moreover, they relate these findings to the future prospect of using DBS to ameliorate motor and cognitive deficits following TBI.

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DBS therapy for the vegetative state and minimally conscious state

Cited by 68 publications

References 8 publications

Diagnostic, pronostic et traitements des troubles de la conscience

Diagnostic, pronostic et traitements des troubles de la conscience

A Review of Neuromodulation in the Neurorehabilitation

Neurostimulation for traumatic brain injury

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