DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors

Abstract

PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.

Cytokine Autoantibodies Are Associated with Infection Risk and Self-Perceived Health: Results from the Danish Blood Donor Study

“…The study includes 8972 blood donors enrolled in 2010 in the first iteration of The Danish Blood Donor Study (DBDS), a nationwide prospective cohort study on blood donor health [17,18]. All participants were healthy at the time of inclusion and between 18 and 67 years of age.…”

Cross‐sectional study identifies lower risk of Staphylococcus aureus nasal colonization in Danish blood donors with hidradenitis suppurativa symptoms

“…Responses to IMQ in patients with PCBCL have been reported before in the literature, but were limited to case reports of one to three patients. [4][5][6] We observed evidence of clinical benefit in about two-thirds of our patients, suggesting that a subset of indolent PCBCL is sensitive to immunomodulatory therapy and that IMQ may have a role in the management of solitary or limited multifocal lesions. We have treated patients until maximum benefit or intolerable local reactions, up-or downtitrating the frequency of administration.…”

“…Study participants were recruited from the Danish Blood Donor Staphylococcus aureus Carriage Study (DBDSaCS, 4 a substudy to the Danish Blood Donor Study, DBDS). 5 Participants were enrolled from May 2015 to August 2019. At inclusion they completed the DBDS electronic questionnaire containing validated HS screening items among other questions, and a nasal swab was taken for the DBDSaCS at the same time.…”

“…Also, the severity of HS cannot be determined from the questionnaire. Institut, Copenhagen, Denmark; 5 Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen; 6 Department of Clinical Immunology and 10 Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 7 Danish Headache Center, Rigshospitalet Glostrup, Glostrup, Denmark; 8 Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark and 11 Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark Email: khoadinh@rm.dk C.E. and O.B.P.…”

“…3 However, data concerning its efficacy in New World CL are scarce and contradictory. [4][5][6][7] Due to a shortage of MA, the Cayenne Hospital started using L-AmB as an alternative in 2015. We conducted a retrospective study to compare the efficacy and safety of L-AmB and MA in patients treated for CL.…”