Daytime Sleep Characteristics and their Relationships with Night Sleep in the Narcoleptic Patient

Billiard, Michel; Mq, Salva; J, De Koninck; Besset, A; Touchon, Jacques; Cadilhac, J

doi:10.1093/sleep/9.1.167

Cited by 35 publications

(10 citation statements)

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“…The narcoleptic SOREM brain state was expected to differ as a function of time of day, particularly between the peak of its occurrence some 3-5 h after morning awakening (Billiard et al, 1986) and the onset of overnight sleep. This gave rise to the following six REM categories across which the cognitive variables were tested: Nocturnal early and late REM in narcoleptics and normals, and daytime and nighttime SOREM in narcoleptics.…”

Section: Resultsmentioning

confidence: 99%

REM Mentation in Narcoleptics and Normals: An Empirical Test of Two Neurocognitive Theories

Fosse

2000

Consciousness and Cognition

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Section: Resultsmentioning

confidence: 99%

REM Mentation in Narcoleptics and Normals: An Empirical Test of Two Neurocognitive Theories

Fosse

2000

Consciousness and Cognition

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“…, 1966; Passouant et al. , 1968), with only a single report suggesting a daytime peak of SOREMP propensity between 12 and 14 h (Billiard et al. , 1986).…”

Section: Discussionmentioning

confidence: 99%

“…Early studies using daytime PSG have also emphasized the specificity of SOREMPs occurring during sleep attacks in NC patients, disregarding circadian times as a covariate (Berti Ceroni et al, 1968;Broughton et al, 1988;Dement et al, 1966;Passouant et al, 1968), with only a single report suggesting a daytime peak of SOREMP propensity between 12 and 14 h (Billiard et al, 1986). Similarly, the absence of SOREMPs during daytime in IH patients has been repetitively documented suggesting that IH could be regarded as a Ônon-REMÕ form of hypersomnia (Berti Ceroni et al, 1967;Billiard et al, 1998;Roth, 1981).…”

Section: Discussionmentioning

confidence: 99%

Daytime continuous polysomnography predicts MSLT results in hypersomnias of central origin

Pizza

Moghadam

Vandi

et al. 2012

Journal of Sleep Research

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SUMMARYIn the diagnostic work-up of hypersomnias of central origin, the complaint of excessive daytime sleepiness should be objectively confirmed by MSLT findings. Indeed, the features and diagnostic utility of spontaneous daytime sleep at 24 h continuous polysomnography (PSG) have never been investigated. We compared daytime PSG features to MSLT data in 98 consecutive patients presenting with excessive daytime sleepiness and with a final diagnosis of narcolepsy with cataplexy ⁄ hypocretin deficiency (n = 39), narcolepsy without cataplexy (n = 7), idiopathic hypersomnia without long sleep time (n = 19), and ÔhypersomniaÕ with normal sleep latency at MSLT (n = 33). Daytime sleep time was significantly higher in narcolepsy-cataplexy but similar in the other groups. Receiver operating characteristics (ROC) curves showed that the number of naps during daytime PSG predicted a mean sleep latency £8 min at MSLT with an area under the curve of 0.67 ± 0.05 (P = 0.005). The number of daytime sleep-onset REM periods (SOREMPs) in spontaneous naps strikingly predicted the scheduled occurrence of two or more SOREMPs at MSLT, with an area under the ROC curve of 0.93 ± 0.03 (P < 10 )12 ). One spontaneous SOREMP during daytime had a sensitivity of 96% with specificity of 74%, whereas two SOREMPs had a sensitivity of 75%, with a specificity of 95% for a pathological REM sleep propensity at MSLT. The features of spontaneous daytime sleep well correlated with MSLT findings. Notably, the occurrence of multiple spontaneous SOREMPs during daytime clearly identified patients with narcolepsy, as well as during the MSLT.

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“…Many of the symptoms of narcolepsy are related to an abnormal tendency to enter REM sleep rapidly, and to express abnormal REM sleep features while awake (e.g., muscle paralysis) or dreaming (hypnagogic hallucinations). Contrary to popular belief, narcolepsy is not characterized by increased total sleep time over the 24-h period [33,34]. Rather, patients with narcolepsy are unable to consolidate either wakefulness or sleep [33,35].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

et al. 2007

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Sleep is a fundamental biological process conserved across the animal kingdom. The study of how sleep regulatory networks are conserved is needed to better understand sleep across evolution. We present a detailed description of a sleep state in adult zebrafish characterized by reversible periods of immobility, increased arousal threshold, and place preference. Rest deprivation using gentle electrical stimulation is followed by a sleep rebound, indicating homeostatic regulation. In contrast to mammals and similarly to birds, light suppresses sleep in zebrafish, with no evidence for a sleep rebound. We also identify a null mutation in the sole receptor for the wake-promoting neuropeptide hypocretin (orexin) in zebrafish. Fish lacking this receptor demonstrate short and fragmented sleep in the dark, in striking contrast to the excessive sleepiness and cataplexy of narcolepsy in mammals. Consistent with this observation, we find that the hypocretin receptor does not colocalize with known major wake-promoting monoaminergic and cholinergic cell groups in the zebrafish. Instead, it colocalizes with large populations of GABAergic neurons, including a subpopulation of Adra2a-positive GABAergic cells in the anterior hypothalamic area, neurons that could assume a sleep modulatory role. Our study validates the use of zebrafish for the study of sleep and indicates molecular diversity in sleep regulatory networks across vertebrates.

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Daytime Sleep Characteristics and their Relationships with Night Sleep in the Narcoleptic Patient

Cited by 35 publications

References 0 publications

REM Mentation in Narcoleptics and Normals: An Empirical Test of Two Neurocognitive Theories

REM Mentation in Narcoleptics and Normals: An Empirical Test of Two Neurocognitive Theories

Daytime continuous polysomnography predicts MSLT results in hypersomnias of central origin

Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

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