Daytime cortisol and stress reactivity in the offspring of parents with bipolar disorder

Ellenbogen, Mark A.; Hodgins, Sheilagh; Walker, Claire‐Dominique; Couture, Sophie; Adam, Sébastien

doi:10.1016/j.psyneuen.2006.08.004

Cited by 98 publications

(68 citation statements)

References 92 publications

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“…Although the direction of effect and causal mechanisms are not known, emotional information processing at an early level of processing, with limited conscious awareness, may represent an important step in regulating the magnitude of the HPA response during stress. The importance of understanding these relationships is particularly evident with respect to disorders such as major depression, in which there is evidence of profound HPA dysregulation (Holsboer, 1995) and cognitive biases toward self-relevant and interpersonal stimuli (Ellenbogen & Schwartzman, 2009;Gotlib et al, 2004), some of which likely precede the development of the disorder (Ellenbogen, Hodgins, Walker, Adam, & Couture, 2006;Ellenbogen, Santo, Linnen, Walker, & Hodgins, 2010;Joormann, Talbot, & Gotlib, 2007). It is likely that deficits in emotional information processing (Leppänen, 2006), amygdala functioning (Ramel et al, 2007), and left prefrontal-amygdala regulatory circuits (Johnstone, van Reekum, Urry, Kalin, & Davidson, 2007) are linked to HPA dysfunction in depression; a better understanding of these relationships will provide new insight into the pathophysiology of this disorder and possibly new modes of therapeutic intervention.…”

Section: Validity Of the Masking Proceduresmentioning

confidence: 99%

Automatic emotional information processing and the cortisol response to acute psychosocial stress

Ellenbogen

Carson

Pishva

2010

Cognitive, Affective, & Behavioral Neuroscience

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Section: Validity Of the Masking Proceduresmentioning

confidence: 99%

Automatic emotional information processing and the cortisol response to acute psychosocial stress

Ellenbogen

Carson

Pishva

2010

Cognitive, Affective, & Behavioral Neuroscience

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“…The TSST-C is a standardized psychosocial stress test consisting of public speaking (finishing a story in as exciting a manner as possible) and arithmetic tasks (serial subtraction) in front of an audience. The TSST-C has been repeatedly demonstrated to induce activation of the HPA axis and the sympathetic adrenomedullary system [23][24][25] . Reduced cortisol responses to the stressor in our patients could not be explained by previous or concurrent treatment with corticosteroids, or differences in personality variables.…”

Section: Stress and Hypothalamus-pituitary-adrenal Axis Function In Amentioning

confidence: 99%

Cortisol Responses to Stress in Allergic Children: Interaction with the Immune Response

Buske‐Kirschbaum

2009

Neuroimmunomodulation

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Allergic manifestations are increasingly common in infants and children. Accumulating evidence suggests that the ‘epidemic’ increase of childhood allergy may be associated with environmental factors such as stress. Although the impact of stress on the manifestation and exacerbation of allergy has been demonstrated, the underlying mechanisms of stress-induced exacerbation are still obscure. A growing number of studies have suggested an altered hypothalamus-pituitary-adrenal (HPA) axis function to stress in allergic children. It is speculated that a dysfunctional HPA axis in response to stress may facilitate and/or consolidate immunological aberrations and thus, may increase the risk for allergic sensitization and exacerbation especially under stressful conditions. In the present review the potential impact of a hyporesponsive as well as a hyperresponsive HPA axis on the onset and chronification of childhood allergy is summarized. Moreover, potential factors that may contribute to the development of an aberrant HPA axis responsiveness in allergy are discussed.

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“…The circadian rhythm of cortisol, or the diurnal cortisol profile, has been implicated in multiple physical and mental health conditions in children and adolescents, including asthma (Wolf et al, 2008;Dreger et al, 2010), bipolar disorder (Ellenbogen et al, 2006), major depression (Van den Bergh and Van Calster, 2009;Adam et al, 2010), and sleep disturbances (El-Sheikh et al, 2008), among others. However, * Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Stability of the diurnal cortisol profile in children and adolescents

Rotenberg

McGrath

Roy-Gagnon

et al. 2012

Psychoneuroendocrinology

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SummaryThe diurnal cortisol profile has been implicated in multiple physical and mental health conditions in children and adolescents; however, current knowledge regarding the stability of the diurnal cortisol profile is largely based on adults. Developmental changes throughout childhood and adolescence warrant examination of the stability of the diurnal cortisol profile during this stage in the lifecourse. The aim of the present study was to conduct a comprehensive evaluation of the diurnal cortisol profile in children and adolescents. Participants (N = 233; M = 12.40, SD = 1.83; 44.2% girls) in the Healthy Heart Project collected saliva samples, completed demographic questionnaires, and recorded bed and waking time. Intra-class correlations were calculated to evaluate the stability of aggregate and single sample measures of the diurnal cortisol profile. Total cortisol concentration (AUC TG , AUC AG ) and maximum sample were the most stable cortisol measures (ICC avg = 0.54). Dynamic measures (AUC I , slope; ICC avg = 0.22) and other single sample measures (awake, lunch, dinner, bedtime, morning random, day random; ICC avg = 0.28) were less stable. Of the developmentally relevant covariates tested, sleep duration, adrenarche, and time of awakening were most associated with cortisol values. Altogether, the diurnal cortisol profile yielded moderate to high stability in children and adolescents. These findings can inform methodological decisions regarding cortisol sampling protocols for children and adolescents. KeywordsCortisol; Stability; Children; Adolescents; HPA axis; Methodology Cortisol, the end product of the hypothalamic pituitary adrenal (HPA) axis, is released in a circadian fashion and in response to stress. The circadian rhythm of cortisol, or the diurnal cortisol profile, has been implicated in multiple physical and mental health conditions in children and adolescents, including asthma (Wolf et al., 2008;Dreger et al., 2010), bipolar disorder (Ellenbogen et al., 2006), major depression (Van den Bergh and Van Calster, 2009;Adam et al., 2010), and sleep disturbances (El-Sheikh et al., 2008), among others. However, * Corresponding author. jennifer.mcgrath@concordia.ca (J.J. McGrath). Conflict of interest statementAll authors declare that they have no conflict of interest.Psychoneuroendocrinology. Author manuscript; available in PMC 2018 January 09.Published in final edited form as: Psychoneuroendocrinology. 2012 December ; 37(12): 1981-1989. doi:10.1016/j.psyneuen.2012.014. CIHR Author ManuscriptCIHR Author Manuscript CIHR Author Manuscript the measurement of cortisol varies widely, and few studies have considered the stability of the diurnal cortisol profile in children and adolescents.The diurnal cortisol profile is characterized by cortisol levels that peak roughly 30 min after awakening (morning acrophase) and gradually decline throughout the day, reaching nadir at bedtime (Fries et al., 2009). The diurnal cortisol profile is described using aggregate measures such as: the awakening response, diurna...

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Daytime cortisol and stress reactivity in the offspring of parents with bipolar disorder

Cited by 98 publications

References 92 publications

Automatic emotional information processing and the cortisol response to acute psychosocial stress

Automatic emotional information processing and the cortisol response to acute psychosocial stress

Cortisol Responses to Stress in Allergic Children: Interaction with the Immune Response

Stability of the diurnal cortisol profile in children and adolescents

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