Day-to-day variability of oscillatory impedance and spirometry in asthma and COPD

Timmins, Sophie; Coatsworth, Nicholas; Palnitkar, Gaurie; Thamrin, Cindy; Farrow, Catherine; Schoeffel, Robin E.; Berend, Norbert; Diba, Chantale; Salome, Cheryl M.; King, Gregory G.

doi:10.1016/j.resp.2012.08.017

Cited by 32 publications

(48 citation statements)

References 48 publications

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“…The within-session variability of R rs was higher than previously reported values of CoV (4% in healthy controls, 7% in asthmatic subjects and 6% in COPD subjects), while the variability of X rs was lower than previously reported values (19% in healthy controls, 22% in asthmatic subjects and 13% in COPD subjects) [12]. However, previous values were collected using different FOT equipment, and represented a within-session repeatability averaged over multiple days excluding day 1, which was shown to have higher variability than subsequent days.…”

Section: Discussioncontrasting

confidence: 70%

“…However, the maximum difference in R rs at 5 Hz in healthy controls was <5%, and the maximum change in X rs in COPD subjects <10%, compared to the reported day-to-day variability of 6.5% for R rs in healthy controls and 23.6% for X rs in COPD subjects [12]. In healthy controls, R rs differed by up to 3% of the predicted value and X rs changed by up to 1% of the predicted value.…”

Section: Discussionmentioning

confidence: 97%

“…Indeed there is limited published data on how duration and number of measurements affect FOT results and its repeatability. While repeatability of FOT measurements is well reported [12–14], these values were acquired with different recording durations, ranging from 8–60 s across multiple centres. A paediatric study [4] has shown that within-session coefficient of variation (CoV) in children decreased with increasing duration of data acquisition.…”

Section: Introductionmentioning

confidence: 99%

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Measurement duration impacts variability but not impedance measured by the forced oscillation technique in healthy, asthma and COPD subjects

et al. 2016

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The forced oscillation technique (FOT) is gaining clinical acceptance, facilitated by more commercial devices and clinical data. However, the effects of variations in testing protocols used in FOT data acquisition are unknown. We describe the effect of duration of data acquisition on FOT results in subjects with asthma, chronic obstructive pulmonary disease (COPD) and healthy controls.FOT data were acquired from 20 healthy, 22 asthmatic and 18 COPD subjects for 60 s in triplicate. The first 16, 30 and 60 s of each measurement were analysed to obtain total, inspiratory and expiratory resistance of respiratory system (Rrs) and respiratory system reactance (Xrs) at 5 and 19 Hz.With increasing duration, there was a decrease in total and expiratory Rrs for healthy controls, total and inspiratory Rrs for asthmatic subjects and magnitude of total and inspiratory Xrs for COPD subjects at 5 Hz. These decreases were small compared to the differences between clinical groups. Measuring for 16, 30 and 60 s provided ≥3 acceptable breaths in at least 90, 95 and 100% of subjects, respectively. The coefficient of variation for total Rrs and Xrs also decreased with duration. Similar results were found for Rrs and Xrs at 19 Hz.FOT results are statistically, but likely minimally, impacted by acquisition duration in healthy, asthmatic or COPD subjects.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Measurement duration impacts variability but not impedance measured by the forced oscillation technique in healthy, asthma and COPD subjects

et al. 2016

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“…Similarly, impedance oscillometry, which assesses airways resistance and capacitance and is effort independent, might be particularly useful in sequential assessment of patients with COPD. 72–74 Impedance oscillometry has been reported to be abnormal in patients with pulmonary symptoms with FEV 1 in the healthy range, and thus might have potential to detect early COPD. 75 The diffusion capacity of the lung for carbon monoxide is reduced in emphysema.…”

Section: Assessment Of Early Copdmentioning

confidence: 99%

Early chronic obstructive pulmonary disease: definition, assessment, and prevention

2015

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Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. COPD, however, is a heterogeneous collection of diseases with differing causes, pathogenic mechanisms, and physiological effects. Therefore a comprehensive approach to COPD prevention will need to address the complexity of COPD. Advances in the understanding of the natural history of COPD and the development of strategies to assess COPD in its early stages make prevention a reasonable, if ambitious, goal.

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“…When measured using FOT, patients with COPD have increased day-to-day variability in impedance compared with healthy control subjects, and even higher than that of patients with asthma (73), despite the fact that COPD is traditionally viewed as a disease of progressive obstruction. Although DFA of respiratory system impedance was not able to differentiate COPD from asthma or healthy control subjects, a distance-based time series analysis was able to distinguish asthma and COPD in the majority of cases (22).…”

Section: Implications For Copd?mentioning

confidence: 99%

Systems Biology and Clinical Practice in Respiratory Medicine. The Twain Shall Meet

Thamrin

Frey

Kaminsky

et al. 2016

Am J Respir Crit Care Med

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Respiratory diseases are highly complex, being driven by host-environment interactions and manifested by inflammatory, structural, and functional abnormalities that vary over time. Traditional reductionist approaches have contributed vastly to our knowledge of biological systems in health and disease to date; however, they are insufficient to provide an understanding of the behavior of the system as a whole. In this Pulmonary Perspective, we discuss systems biology approaches, especially but not limited to the study of the lung as a complex system. Such integrative approaches take into account the large number of dynamic subunits and their interactions found in biological systems. Borrowing methods from physics and mathematics, it is possible to study the collective behavior of these systems over time and in a multidimensional manner. We first examine the physiological basis for complexity in the respiratory system and its implications for disease. We then expand on the potential applications of systems biology methods to study complex systems, within the context of diagnosis and monitoring of respiratory diseases including asthma, chronic obstructive pulmonary disease (COPD), and critical illness. We summarize the significant advances made in recent years using systems approaches for disease phenotyping, applied to data ranging from the molecular to clinical level, obtained from large-scale asthma and COPD networks. We describe new studies using temporal complexity patterns to characterize asthma and COPD and predict exacerbations as well as predict adverse outcomes in critical care. We highlight new methods that are emerging with this approach and discuss remaining questions that merit greater attention in the field.

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Day-to-day variability of oscillatory impedance and spirometry in asthma and COPD

Cited by 32 publications

References 48 publications

Measurement duration impacts variability but not impedance measured by the forced oscillation technique in healthy, asthma and COPD subjects

Measurement duration impacts variability but not impedance measured by the forced oscillation technique in healthy, asthma and COPD subjects

Early chronic obstructive pulmonary disease: definition, assessment, and prevention

Systems Biology and Clinical Practice in Respiratory Medicine. The Twain Shall Meet

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