Day-to-day variability of adequacy indexes in peritoneal dialysis

Abstract

Evaluating the adequacy of PD by means of a single measurement should take into account the weekly variability as demonstrated by a triple dialysate and urine collection. Standard adequacy targets can be corrected to allow for variability. Thus one can obtain safe values for prescription decisions based on a single collection result.

Comparison between creatinine-based equations for estimating total creatinine clearance in peritoneal dialysis: a multicentre study

“…Taking into account that the coefficient of variability of the totCrCL in PD patients, using three CL measurements over a 1-week period, was reportedly 6.0% [23] and 9.4% [34], the real MAPE of the equations studied could be calculated by subtracting the value of their variability: for example, 14%-6% = 8% (Gates). In fact, ∼42% of the total variability is due to the variability in the single fluid collections (see Statistics).…”

“…To establish the real estimative value of these equations, we considered the coefficient of variability deriving from differences in single fluid collections, drawn from our published data [23] (in three dialysate and urine collections taken within 7 days from 24 PD patients, the coefficient of variability for totCrCL was 6%). From the within-subject and intersubject variances for totCrCL (53.68, SD = 7.33 and 75.01, SD = 8.66, respectively), we obtained the total variance (128.69, SD = 11.34), so the (within/total variance) * 100, i.e.…”

Cross-Over Efficiency Comparison of Different Tidal Automated Peritoneal Dialysis Schedules

“…The observed variability of the results [11] with the same schedule for the variables studied is given in 291 prescribed FV ratio of 1.06 ± 0.3, while some overfilling was frequently registered during breakpoint sessions, with a mean ratio of 1.25 ± 1. Differences were found neither in drainage alarms incidence nor in subjectively perceived comfort and sleep quality indexes.…”

“…No significant difference was found in variability between the different treatments. CV = Coefficient of variation calculated according to the formula (CV% = SD/M × 100) already described elsewhere [11]. 13] , tidal APD use is growing among APD patients mainly because of better PD fluids dynamics, better patient's comfort, reduced drainage pain and alarms and better quality of sleep [8] .…”

Risk factors for increased variability in dialysis delivery in haemodialysis patients

“…The use of a venous tunnelled catheter and dialysis in a total nursing-care unit were the only factors independently associated with greater variability in both VBP and URR, as measured by the CV%, a commonly used and accepted measure of variability [10,11]. In addition, it was demonstrated that greater variability in the VBP was a major contributor to inadequate dialysis delivery, as measured by the URR.…”