Day-to-day intraindividual reliability and interindividual differences in monoamines excretion

Curtin, François; Walker, Jean-Pierre; Schulz, Pierre

doi:10.1016/0165-0327(96)00011-0

Cited by 18 publications

(19 citation statements)

References 42 publications

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“…The 24-h urinary EPI excretion did not correlate with the monocyte percentages and absolute monocyte count (r ϭ Ϫ0.07 and 0.01, respectively; data not shown), suggesting that baseline EPI affects monocytic activity but not monocyte number. In our study cohort, the urinary EPI output ranged from 0.85 to 13.5 g/24 h. Similarly to a previous study (31), the 24-h urinary EPI excretion assessed on 2 consecutive days showed relatively wide but stable interindividual variability (r ϭ 0.70, p Ͻ 0.05, EPI excretion on day 1 vs EPI excretion on day 2; data not shown). The 24-h urinary EPI excretion correlated positively and significantly with the 24-h urinary-free cortisol excretion (r ϭ 0.22, p Ͻ 0.05; data not shown), indicating an association between the baseline activity of the adrenal medulla and cortex in healthy subjects.…”

Section: Correlation Between Adrenomedullary Activity and Innate Cytosupporting

confidence: 54%

Low- versus High-Baseline Epinephrine Output Shapes Opposite Innate Cytokine Profiles: Presence of Lewis- and Fischer-Like Neurohormonal Immune Phenotypes in Humans?

Elenkov

Květňanský

Hashiramoto

et al. 2008

The Journal of Immunology

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Immunogenetic mechanisms operating within the immune system are known to influence cytokine profiles and disease susceptibility. Yet the role of the individual’s neurohormonal background in these processes remains undefined. Hormonal imbalances are documented in immune-related diseases, but it is unclear whether this represents a secondary phenomenon or a primary “defect” related to specific neurohormonal immune phenotype(s). We report that in a large subpopulation of healthy humans the baseline epinephrine output (but not cortisol and sex steroid hormones) correlated inversely with proinflammatory and positively with anti-inflammatory cytokine production. Thus, low vs high epinephrine excretors had a 2- to 5-fold higher TNF-α and IL-12 production but 2-fold lower IL-10 production induced by LPS ex vivo. In alternative settings, we found low baseline levels and profoundly blunted stress-induced epinephrine responses but high TNF-α levels in Lewis vs Fischer inbred rats. Additionally, isoproterenol, a β adrenoreceptor agonist suppressed LPS-induced TNF-α production, with more pronounced effect in Lewis than in Fischer rats. In human monocytes, epinephrine and the β2 adrenoreceptor agonist fenoterol potently inhibited LPS-induced TNF-α and IL-12, but stimulated IL-10 production. The order of potency for hormones able to inhibit IL-12 production ex vivo was: epinephrine > norepinephrine > = 1,25-(OH)2 vitamin D3 > hydrocortisone. This indicates that baseline epinephrine conditions cytokine responsiveness and through this mechanism intrinsic hypo- or hyperactive adrenal medullas in some individuals may shape opposite cytokine profiles. Since Lewis and Fischer rats have opposite susceptibility to experimental immunological diseases, this suggests that the parallel human phenotypes could be linked to differing responsiveness and susceptibility to infections and immune/inflammatory-related conditions.

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Section: Correlation Between Adrenomedullary Activity and Innate Cytosupporting

confidence: 54%

Low- versus High-Baseline Epinephrine Output Shapes Opposite Innate Cytokine Profiles: Presence of Lewis- and Fischer-Like Neurohormonal Immune Phenotypes in Humans?

Elenkov

Květňanský

Hashiramoto

et al. 2008

The Journal of Immunology

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“…Compared with HRV and catecholamine metabolite output, 26 salivary cortisol secretion exhibits greater biological variability (intraclass correlation of 0.3 over 2 days), and this may account for our null findings. Alternatively, higher corticosteroid excretion in the metabolic syndrome may not be accompanied by increased circulating cortisol concentrations if there is raised peripheral cortisol metabolism.…”

Section: Brunner Et Al Metabolic Syndrome and Autonomic Function 2663contrasting

confidence: 44%

Adrenocortical, Autonomic, and Inflammatory Causes of the Metabolic Syndrome

Brunner¹,

Hemingway²,

Walker³

et al. 2002

Circulation

482

288

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Background-The causes of metabolic syndrome (MS), which may be a precursor of coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and cardiac autonomic activity (CAA) contribute to development of MS. We examine reversibility and the power of psychosocial and behavioral factors to explain the neuroendocrine adaptations that accompany MS. Methods and Results-This was a double-blind case-control study of working men aged 45 to 63 years drawn from the Whitehall II cohort. MS cases (nϭ30) were compared with healthy controls (nϭ153). Cortisol secretion, sensitivity, and 24-hour cortisol metabolite and catecholamine output were measured over 2 days. CAA was obtained from power spectral analysis of heart rate variability (HRV) recordings. Twenty-four-hour cortisol metabolite and normetanephrine (3-methoxynorepinephrine) outputs were higher among cases than controls (ϩ0.49, ϩ0.45 SD, respectively). HRV and total power were lower among cases (both Ϫ0.72 SD). Serum interleukin-6, plasma C-reactive protein, and viscosity were higher among cases (ϩ0.89, ϩ0.51, and ϩ0.72 SD). Lower HRV was associated with higher normetanephrine output (rϭϪ0.19; Pϭ0.03). Among former cases (MS 5 years previously, nϭ23), cortisol output, heart rate, and interleukin-6 were at the level of controls. Psychosocial factors accounted for 37% of the link between MS and normetanephrine output, and 7% to 19% for CAA. Health-related behaviors accounted for 5% to 18% of neuroendocrine differences. Conclusions-Neuroendocrine stress axes are activated in MS. There is relative cardiac sympathetic predominance. The neuroendocrine changes may be reversible. This case-control study provides the first evidence that chronic stress may be a cause of MS. Confirmatory prospective studies are required.

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“…Curtin reported distinct differences among the urinary catecholamines for both the CV i and CV g [23], while very similar CV i and CV g variability for the catecholamines were observed by Souza [24]. Additionally, the ratio of the CV i and CV g for the urinary catecholamines varied significantly [21][22][23][24].…”

Section: Introductionmentioning

confidence: 57%

“…However, very limited data are available for CV i and CV g of catecholamine excretions under free-living conditions in healthy individuals [21][22][23][24]. Curtin reported distinct differences among the urinary catecholamines for both the CV i and CV g [23], while very similar CV i and CV g variability for the catecholamines were observed by Souza [24].…”

Section: Introductionmentioning

confidence: 76%

Development and validation of a specific and sensitive LC-MS/MS method for quantification of urinary catecholamines and application in biological variation studies

Li¹,

Li²,

Wynveen³

et al. 2014

Anal Bioanal Chem

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Catecholamines are a class of biogenic amines that play an important role as neurotransmitters and hormones. We developed and validated a rapid, specific and sensitive LC-MS/MS method for quantitative determination of catecholamines in human urine. Linearity, specificity, sensitivity, precision, accuracy, matrix effect, carryover, analyte stability, method comparison and reference range were evaluated. The catecholamine measurements were not affected by 35 structurally-related drugs and metabolites. The outstanding specificity was achieved by use of a specific diphenylborate-based solid phase extraction and subsequent selective LC-MS/MS analysis. Excellent sensitivity, accuracy and precision (average intra-assay variations <2.9 % and inter-assay variations <4.6 %) were obtained. The method was successfully applied in the study of day-to-day biological within- and between-subject variations of 25 healthy people under free-living conditions over three consecutive days. We observed that catecholamine excretions for second morning sampling had least day-to-day within-subject variation and excellent reproducibility. This work is one of the rare studies on these topics and represents the first utilization of advanced LC-MS/MS technology. Additionally, we found significant correlations between spot and conventional 24 h collections of human urine (n = 22, r > 0.853, p < 0.0001). These findings suggest that determining the catecholamine concentrations in the second morning urine sample presents accurate, convenient and reliable measurement of catecholamine excretions. In addition, consistent and significant diurnal variations for norepinephrine and epinephrine excretions were observed during the three-day period, while dopamine did not exhibit a diurnal rhythm. The LC-MS/MS method presented here is rapid, sensitive and specific, which could be an advantage in clinical laboratories.

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Day-to-day intraindividual reliability and interindividual differences in monoamines excretion

Cited by 18 publications

References 42 publications

Low- versus High-Baseline Epinephrine Output Shapes Opposite Innate Cytokine Profiles: Presence of Lewis- and Fischer-Like Neurohormonal Immune Phenotypes in Humans?

Low- versus High-Baseline Epinephrine Output Shapes Opposite Innate Cytokine Profiles: Presence of Lewis- and Fischer-Like Neurohormonal Immune Phenotypes in Humans?

Adrenocortical, Autonomic, and Inflammatory Causes of the Metabolic Syndrome

Development and validation of a specific and sensitive LC-MS/MS method for quantification of urinary catecholamines and application in biological variation studies

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