vary in accordance with the frequency of risk factors [4]. Each year, approximately 750,000 new cases are diagnosed, risk factors include pre-existing infection with hepatitis B or C viruses and cirrhosis [5,6].The diagnosis of HCC in our study was made based on radiological criteria according to the AASLD guidelines [7,8].Bone metastases (BM) are rare in patients with early-stage hepatocellular carcinoma (HCC) [9]. In some centers, liver transplantation (LT) policies require patients with HCC to undergo bone scans.Bone scintigraphy was performed using a dual-head gamma camera equipped with general-purpose collimators. Anterior and posterior whole-body images were acquired approximately 3 hours after intravenous administration of 925 MBq 99mTc-hydroxymethane diphosphonate (HDP). Additional static planar images were acquired at the discretion of the attending nuclear physician. The results of each bone scan were classified as follows: (i) positive for metastases (defined as focal uptake of the radiotracer in non-physiologic locations that could not be explained by other conditions, such as trauma, known degenerative diseases, or inflammation); (ii) negative for metastases (physiologic uptake alone or uptake with a distribution consistent with recent trauma or known degenerative diseases); or (iii) suspicious for BM (increased uptake in non-physiologic locations without characteristics of metastases, such as isolated focal uptake) [10] Our program utilizes bone scan routinely in the pretransplant evaluation of patients with hepatocellular carcinoma (HCC). The aim of our study is to evaluate the utility of bone scan in the setting of the pre-transplant liver workup in HCC patient.
MethodThis is a retrospective chart review of our liver transplant (LT) database of all patients with HCC who underwent bone Abstract Background and Aims: Our program utilizes bone scan routinely as part of liver transplant (LT) evaluation of patients with hepatocellular carcinoma (HCC). The aim of this study is to evaluate the utility of bone scan in the pre-transplant workup.