Day Napping and Short Night Sleeping Are Associated With Higher Risk of Diabetes in Older Adults

Xu, Qun; Song, Yiqing; Hollenbeck, Albert R.; Blair, Aaron; Schatzkin, Arthur; Chen, Honglei

doi:10.2337/dc09-1143

Cited by 137 publications

(161 citation statements)

References 24 publications

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“…A recent meta-analysis combining data from 90,623 individuals concluded that for short sleep duration (#5-6 h per night), the relative risk of developing diabetes was 1.28 after controlling for multiple factors (17). Not included in this meta-analysis is the largest study to date (18), which included 174,542 adults and observed that individuals who report sleeping <5 h per night, relative to those reporting 7-8 h per night, had a 46% higher risk of developing type II diabetes, after controlling for multiple confounders, including adiposity.…”

Section: Epidemiologic Evidence For a Link Between Sleep Disturbancesmentioning

confidence: 99%

Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism

Hanlon

Cauter

2011

Proc. Natl. Acad. Sci. U.S.A.

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Rates of obesity have been steadily increasing, along with disorders commonly associated with obesity, such as cardiovascular disease and type II diabetes. Simultaneously, average sleep times have progressively decreased. Recently, evidence from both laboratory and epidemiologic studies has suggested that insufficient sleep may stimulate overeating and thus play a role in the current epidemic of obesity and diabetes. In the human sleep laboratory it is now possible to carefully control sleep behavior and study the link between sleep duration and alterations in circulating hormones involved in feeding behavior, glucose metabolism, hunger, and appetite. This article focuses on the methodologies used in experimental protocols that have examined modifications produced by sleep restriction (or extension) compared with normal sleep. The findings provide evidence that sleep restriction does indeed impair glucose metabolism and alters the cross-talk between the periphery and the brain, favoring excessive food intake. A better understanding of the adverse effects of sleep restriction on the CNS control of hunger and appetite may have important implications for public health.

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Section: Epidemiologic Evidence For a Link Between Sleep Disturbancesmentioning

confidence: 99%

Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism

Hanlon

Cauter

2011

Proc. Natl. Acad. Sci. U.S.A.

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“…In addition, without a dose-response analysis, it remains unknown how many hours of habitual sleep are associated with the lowest risk of type 2 diabetes. In the past several years, the number of prospective studies with enough quantitative categories has nearly doubled (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). Therefore, we conducted a meta-analysis of prospective studies to determine the overall shape of the relationship between sleep duration and risk of type 2 diabetes.…”

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confidence: 99%

Sleep Duration and Risk of Type 2 Diabetes: A Meta-analysis of Prospective Studies

et al. 2015

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OBJECTIVEIt remains unclear how many hours of sleep are associated with the lowest risk of type 2 diabetes. This meta-analysis was performed to assess the dose-response relationship between sleep duration and risk of type 2 diabetes. RESEARCH DESIGN AND METHODSPubMed and Embase were searched up to 20 March 2014 for prospective observational studies that assessed the relationship of sleep duration and risk of type 2 diabetes. Both semiparametric and parametric methods were used. RESULTSTen articles with 11 reports were eligible for inclusion in the meta-analysis. A total of 18,443 incident cases of type 2 diabetes were ascertained among 482,502 participants with follow-up periods ranging from 2.5 to 16 years. A U-shaped dose-response relationship was observed between sleep duration and risk of type 2 diabetes, with the lowest risk observed at a sleep duration category of 7-8 h per day. Compared with 7-h sleep duration per day, the pooled relative risks for type 2 diabetes were 1.09 (95% CI 1.04-1.15) for each 1-h shorter sleep duration among individuals who slept <7 h per day and 1.14 (1.03-1.26) for each 1-h increment of sleep duration among individuals with longer sleep duration. CONCLUSIONS

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“…Compelling epidemiological evidence suggests a link between insufficient sleep and an increased risk of high BMI, obesity and/or type 2 diabetes [61][62][63][64]. Combining data obtained from 90 623 individuals, Cappuccio et al concluded that individuals who report sleeping less than 5 h each night have a 46% higher risk of developing type 2 diabetes compared to individuals who sleep 7-8 h each night [64].…”

Section: Sleep Deprivation and The Effect On Metabolismmentioning

confidence: 99%

Plasticity of circadian clocks and consequences for metabolism

Coomans

Lucassen

Kooijman

et al. 2015

Diabetes Obesity Metabolism

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The increased prevalence of metabolic disorders and obesity in modern society, together with the widespread use of artificial light at night, have led researchers to investigate whether altered patterns of light exposure contribute to metabolic disorders. This article discusses the experimental evidence that perturbed environmental cycles induce rhythm disorders in the circadian system, thus leading to metabolic disorders. This notion is generally supported by animal studies. Distorted environmental cycles, including continuous exposure to light, affect the neuronal organization of the central circadian pacemaker in the suprachiasmatic nucleus (SCN), its waveform and amplitude of the rhythm in electrical activity. Moreover, repeated exposure to a shifted light cycle or the application of dim light at night are environmental cues that cause a change in SCN function. The effects on the SCN waveform are the result of changes in synchronization among the SCN's neuronal cell population, which lead consistently to metabolic disturbances. Furthermore, we discuss the effects of sleep deprivation and the time of feeding on metabolism, as these factors are associated with exposure to disturbed environmental cycles. Finally, we suggest that these experimental studies reveal a causal relationship between the rhythm disorders and the metabolic disorders observed in epidemiological studies performed in humans. Keywords: circadian, desynchronization, suprachiasmatic nucleus, metabolic disorders, light Date submitted 11 April 2015; date of final acceptance 17 May 2015 Environmental Effects on the Rhythm of the SCNPerturbations in the circadian rhythm can develop under a variety of conditions, including ageing, neurodegenerative diseases and metabolic disorders. In order to effectively treat these diseases, it is important to elucidate the causal relationships behind these associations. Towards that end, several animal models have been used to specifically address the relationship between circadian disorders and metabolic disturbances. These models include transgenic mouse models with specific mutations in clock genes, as well as animals in which the function of the suprachiasmatic nucleus (SCN) has been altered by manipulating environmental cues. Transgenic models have been particularly valuable for elucidating the signalling pathways involved in the pathogenesis of metabolic disorders such as diabetes and obesity [1]. Moreover, performing complementary studies in wild-type animals and studying the effect of the environment on SCN functions are valuable as well, given the growing body of evidence suggesting that improper circadian timing interferes with health. For example, sleep disruption in humans is correlated with an increased risk of developing diabetes, and shift work has been associated with increased body mass index (BMI), altered plasma lipids and impaired insulin sensitivity [2][3][4] (Table 1). These studies indicate a potentially large influence of stable, robust environmental light-dark cycles on the maintenance o...

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Day Napping and Short Night Sleeping Are Associated With Higher Risk of Diabetes in Older Adults

Cited by 137 publications

References 24 publications

Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism

Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism

Sleep Duration and Risk of Type 2 Diabetes: A Meta-analysis of Prospective Studies

Plasticity of circadian clocks and consequences for metabolism

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