Day-3 embryo morphology predicts euploidy among older subjects

Over Ten-Cell Good Embryo Transfers on Day Three have Equivalent Clinical Outcomes with Those of Eight-Cell Embryos in Female Patients Aged ≤35 Years: A Retrospective Cohort Study

“…Likewise, a study by Luna et al [13] suggested that faster embryos (> 10-cell) on day 3 result in better blastocysts. In addition, the result is in agreement with another retrospective study which suggested that cellular fragmentation rather than cell number is a more sensitive proxy for selecting chromosomally normal embryos in IVF/ICSI cycles [14]. It seemed that faster developing embryos on day 3 had comparable implantation potential with normally progressing embryos.…”

Perinatal outcomes of patients who achieved pregnancy with a morphologically poor embryo via assisted reproductive technology

“…These embryos have more than 7-cell stage with more than 20 % of fragmentation or less than a 7-cell stage with less than 20 % of fragmentation. A recent report indicated that a day 3 embryo morphology could be used to predict euploidy among older patients [21]. That report showed that embryos with a low proportion of fragmentation but a slow developmental speed might not increase the possibility of aneuploidy.…”

Blastocyst morphology holds clues concerning the chromosomal status of the embryo

“…Although preliminary, these studies have shown a weak association between aneuploidy and abnormal embryo morphology. (2,(5)(6)(7)(11)(12)(13). Alfarawati et al (2) showed that aneuploidy negatively affected the ICM and TE grades.…”

“…At diagnosis, we considered embryos as normal when two sex chromosomes and two chromosomes (13,14,15,16,18, 21 and 22) were present. They were considered trisomic or monosomic, respectively, if an extra or missing signal was observed.…”