Daxx knockdown promoted rDNA transcription without impairing H3.3 expression in mouse preimplantation embryos
Sihang Song,
Nan Wang,
Xing‐wei Huang
et al.
Abstract:During fertilization, DAXX (death domain‐associated protein) mediates histone variant H3.3 incorporation into heterochromatin, which plays an important role in the maintenance of genomic integrity. rDNA, the ribosomal gene, is included in the first wave of gene activation after fertilization. Our and other studies indicated that loss of Daxx disturbs rDNA heterochromatinization and promotes rDNA transcription without change in protein expression of H3.3. However, maternal and zygotic deletion of Daxx impairs b… Show more
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