Davidones F and G, Two Novel Flavonoids from Sophora davidii (Franch.) Skeels

Abstract

An unprecedented novel flavanone davidone F (1) with a seven-membered ring side chain, and a novel flavanonol davidone G (2), along with 11 known flavonoids, were isolated from the ethyl acetate fraction of Sophora davidii (Franch.) Skeels. Their planar structures were established by UV, IR, HRESIMS, 1D and 2D NMR data. The relative configurations of 1 and 2 were determined by calculation of NMR chemical shift values, the absolute configuration of 1 and 2 were assigned by comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Moreover, compounds 1–13 were screened for the translocation activity of glucose transporter 4 (GLUT-4), and the fluorescence intensity was increased to the range of 1.56 and 2.79 folds. Compounds 1 and 2 showed moderate GLUT-4 translocation activity with 1.64 and 1.79 folds enhancement, respectively, at a concentration of 20 μg/mL.

Flavonoids From the Aerial Parts of Sophora tonkinensis and Their Potential Anti‐Inflammatory Activities

“…The original HRESIMS, UV, IR, NMR, CD spectra for new compounds 1-4 and the NMR data for known analogues (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) are provided in the supplementary material.…”

“…In particular, prenylation of prenylated flavonoids adds to the lipophilicity of flavonoids, leading to an increase in their affinity for biological receptors. [10,11] Currently, a demand for rhizomes and their supplies exists. However, twigs and leaves are non-medicinal parts, that are usually discarded during harvesting, leading to wastage of resources and environmental pollution.…”

“…Flavonoids, which are the main compounds in S. tonkinensis , exhibit extensive biological activities. In particular, prenylation of prenylated flavonoids adds to the lipophilicity of flavonoids, leading to an increase in their affinity for biological receptors [10,11] . Currently, a demand for rhizomes and their supplies exists.…”