David Kimhi

Talmage, Frank

doi:10.4159/harvard.9780674433724

Cited by 121 publications

(3 citation statements)

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“…Electron microscopic studies show these cells respond rapidly and distinctively to calcitonin [9]. Also, in a recent report we have presented additional data suggesting that calcitonin moves phosphate into, and prevents its loss from, bone fluid [17]. Finally, the rapid formation of lead-calcium-phosphate colloids in plasma and the high affinity of lead for phosphate suggest that the calcium-phosphate compounds formed in bone fluid could be the site of rapid sequestering of lead from plasma.…”

Section: Discussionmentioning

confidence: 88%

A study of the action of calcitonin by its effects on lead-induced hypercalcemia

Talmage

VanderWiel

1979

Calcif Tissue Int

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Summary. Intravenous (i.v.) injection of lead acetate produces an immediate elevation in total plasma calcium and phosphate levels. This is due to the formation of calcium-phosphate compounds which can be removed by centrifugation at 25,000 • g. For this study, the effect of salmon calcitonin (CT) on these lead-induced plasma changes was studied. Intact male rats (175-250 g) were injected i.v. with lead acetate 10-30 mg/kg. Sodium acetateinjected rats served as controls. CT (0.1-0.2 mU/g) injected 30 min prior to lead modified the lead-induced plasma changes as follows: The concentration of lead remaining in plasma was statistically reduced. This was accompanied by a decrease in the amount of colloidal calcium-phosphate removed by ultracentrifugation and a corresponding decrease in the lead-induced elevation of total plasma calcium and phosphate levels. This action of CT was still effective in acutely nephrectomized rats. However, a 15-day pretreatment with a diphosphonate (20 mg EHDP/kg/day) abolished the hypocalcemic effect of CT and also abolished the ability of CT to affect the lead-induced plasma changes. Finally, CT was ineffective if injected in as short a time period as 30 min after lead injection.It is concluded from these studies that CT causes a rapid sequestering of lead from plasma into specific sites in bone. Previous reports show that within minutes after injection, CT causes the formation of calcium-phosphate complexes in fluid at the surfaces of bone and in osteocyte lacunae. It is postulated that lead reacts with these colloids (complexes) in a manner similar to its attachment to calcium and phosphate in plasma, thereby removing this lead from blood.Send qffprint requests to Dr. Roy V. Talmage at the above address.

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Section: Discussionmentioning

confidence: 88%

A study of the action of calcitonin by its effects on lead-induced hypercalcemia

Talmage

VanderWiel

1979

Calcif Tissue Int

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“…44 By the twelfth century, Rabbinic scholars like David Kimhi (1160-1235) were adding to the depth of the Hebraic tradition itself, with commentaries on the books of the Prophets, studies of grammar, and further refinements to the niqqud, or pronunciation of Biblical words. 45 This was a tradition that thrived on commentary and deep reading of the texts in order to recover often hidden and esoteric levels of meaning, which explains its appeal to the sensibilities of Renaissance humanists. 46 Kimhi's works were thus taken up by Pico della Mirandola (1463-94) and Johann Reuchlin (1455-1522), who found disciples among the reform-minded community of Catholic scholars in England.…”

Section: Hebraism and Historymentioning

confidence: 99%

Hebraism and the problem of church and state in England, 1642–1660

Prior

2013

The Seventeenth Century

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This essay examines the use of Hebrew sources in debates on church and state in civil war England. It fits within a developing historiography that seeks to uncover the deeper texture of early modern political discourse, and also poses questions about the prevalence of statist and secular understandings of public power in the context of the English civil war. Its specific focus is on debates on church government in the 1640s, studies of the Hebrew commonwealth in the 1650s, and the use of Hebraism by Hobbes and Harrington as an antidote to clericalism.

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“…It has previously been reported by Talmage cl al. [25] that supernatants harvested from Con A-stimulated spleen cells ean support cytotoxie responses to UVirradiated stimulator cells. Here we compared the efficacy of syngeneic PEC and costitnulator in the aciivalion of CL lo UV-and v-irradiated slitniilator spleen cells ( Fig.…”

Section: Cosiitnttlator Latt Stihstltttte For Pec Requirentent In Ctimentioning

confidence: 98%

A Two‐Signal Mechanism for the Induction of Cytotoxic T Lymphocytes

Symington

Teh

1980

Scand J Immunol

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Depletion of adherent cells from stimulator and responder lymphocytes by a single filtration through nylon wool columns led to complete abrogation of the cytotoxic response to the stimulating alloantigen. Cytotoxic responses were restored by adding anti-Thy-1 + complement-greated normal peritoneal exudate cells (PEC) syngeneic or allogeneic to the responding population. Alternatively, the response could be reconstituted with costimulator, a lymphokine obtained by stimulation of spleen cells with concanavalin A. Costimulator was not itself cytotoxic and induced few or no cytotoxic T lymphocytes (CL) in the absence of stimulator cells. Costimulator was also more efficient than allogeneic PEC, which in turn were more efficient than syngeneic PEC, in reconstituting the cytotoxic response. The number of CL produced to the activating alloantigen was shown to increase with increasing concentration of costimulator. More interestingly, in the presence of a relatively high concentration of costimulator, CL were also activated to target cells that differ in H-2 haplotype from the stimulating alloantigen. Lysis of the third-party target cells could not be inhibited by cold targets syngeneic to the activating alloantigen. A clonal assay for cytotoxic precursors was used to confirm that CL for the activating alloantigen and CL for the third-party H-2 antigens were derived from different progenitors. Only about 37% of the cytotoxic clones produced were specific for the activating alloantigen. These observations are explained in terms of a two-signal model of CL activation.

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David Kimhi

Cited by 121 publications

References 0 publications

A study of the action of calcitonin by its effects on lead-induced hypercalcemia

A study of the action of calcitonin by its effects on lead-induced hypercalcemia

Hebraism and the problem of church and state in England, 1642–1660

A Two‐Signal Mechanism for the Induction of Cytotoxic T Lymphocytes

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