Daudi supernatant, unlike other H-Y antigen sources, exerts a sex-reversing effect on embryonic chick gonad differentiation

Hendriksen, Peter J.M.; Drews, Ulrich; Frankenhuis, M. T.; Veerhuis, Robert; Hengst, S.; Wagner, Uli; Braun, S.; Booman, P.

doi:10.1007/bf00190588

Cited by 2 publications

(2 citation statements)

References 47 publications

(44 reference statements)

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“…As source of H-Y antigen the human Burkitt lymphoma Daudi cell line carrying an XY sex chromosome complement was used (Ohno et al, 1979). In this context we finally observed, that the sex reversing effect of Daudi supernatant was not due to H-Y antigen but to another not yet characterized factor (Hendriksen et al, 1994). The highest ranking species is the opossum, in which an influence of the sex hormones was observed (Burns, 1959).…”

Section: Gonadal Sex Determinationmentioning

confidence: 89%

Local mechanisms in sex specific morphogenesis

Drews

2000

Cytogenet Genome Res

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Sex determination in mammals occurs on three levels. Segregation of sex chromosomes determines the chromosomal sex. Sry on the Y chromosome induces formation of a testis which in turn regulates via AMH and testosterone the development of the genital tract and the external phenotype. Recently a number of new factors have been described, which affect sexual development but have not yet found a place in the above canonical scheme of sex determination. For the purpose of this review, the factors are aligned according to their quality as transcription factors, steroid hormones, or growth factors. In this web of regulatory factors, the classical sex determining factors have evolved as master mechanisms while others function as slaves, or were totally suppressed. In this context, androgens acquired a dominant role in mammalian development. Androgens determine the morphogenesis of the genital tract. The effects of androgens are mediated by local cellular interactions. In the cranial section of the Wolffian duct the androgen receptor appears in the epithelium and mediates maintenance of the duct via an epithelial factor. In the caudal section of the duct the androgen receptor is expressed in the embryonic mesenchyme. Vesicular glands are induced via a morphogenetically active mesenchymal condensation, while the epithelial buds are primarily AR androgen receptor negative. The dominant role of androgens and formation of a vagina evolved together at the transition to eutherian mammals. Under this aspect, the role of androgens in the development of the vagina is analyzed.

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Section: Gonadal Sex Determinationmentioning

confidence: 89%

Local mechanisms in sex specific morphogenesis

Drews

2000

Cytogenet Genome Res

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“…Therefore, the antigen derived from these two sources should be similar not only with respect to its antigenicity, but also functionally. However, Hendriksen et al (1994), while confirming a sex reversing effect of Daudi supernatant, provided some evidence, within the limits of the methods used, that the responsible factor is different from H-Y antigen.…”

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confidence: 99%

The serologically detected H-Y antigen revisited

Wolf¹

1998

Cytogenet Genome Res

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H-Y antigen has been defined by various immunological methods including graft rejection, T-cell mediated cytolysis, and antiserum cytotoxicity. The H-Y phenotype is normally associated with the male sex in mammals. Using specific T-cell clones, two Y-linked genes coding for H-Y epitopes have been identified in the mouse, Smcy and Uty, and one of these genes, SMCY, is also present on the human Y chromosome. Anti-H-Y antisera detect a membrane bound antigen associated with β₂-microglobulin, and a soluble protein secreted by testicular Sertoli cells. The membrane bound antigen appears to be different from the peptides detected by cytotoxic T-cells, and for the soluble antigen evidence was provided that, in mammals it may be identical with anti-Müllerian hormone. In non-mammalian vertebrates, serological H-Y antigen is associated with the heterogametic sex, and sex-reversal of the homogametic sex results in the occurrence of H-Y antigen. Originally, H-Y antigen was believed to be responsible for sex determination, thus representing the testis-determining factor (TDF) in mammals, but this hypothesis has been disproved by showing that male gonadal differentiation can also occur (in the mouse) in the absence of H-Y antigen. In the meantime, SRY is considered to be TDF. Although it was revealed that the H-Y antigens as detected by different assays are genetically heterogeneous, they are probably involved in male-specific functions in mammals, and possibly in the differentiation of the heterogametic sex in non-mammalian vertebrates.

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Daudi supernatant, unlike other H-Y antigen sources, exerts a sex-reversing effect on embryonic chick gonad differentiation

Cited by 2 publications

References 47 publications

Local mechanisms in sex specific morphogenesis

Local mechanisms in sex specific morphogenesis

The serologically detected H-Y antigen revisited

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